Role of E2F transcription factor in oral cancer: Recent insight and advancements
The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and differentiation, mainly in a cell cycle-depende...
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2023
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| Online Access: | http://dx.doi.org/10.1016/j.semcancer.2023.03.004 https://www.sciencedirect.com/science/article/pii/S1044579X23000378 http://hdl.handle.net/10576/42577 |
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| _version_ | 1857415084467290112 |
|---|---|
| author | Amal, Kassab |
| author2 | Gupta, Ishita Moustafa, Ala-Eddin Al |
| author2_role | author author |
| author_facet | Amal, Kassab Gupta, Ishita Moustafa, Ala-Eddin Al |
| author_role | author |
| dc.creator.none.fl_str_mv | Amal, Kassab Gupta, Ishita Moustafa, Ala-Eddin Al |
| dc.date.none.fl_str_mv | 2023-05-11T06:15:14Z 2023-03-15 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.semcancer.2023.03.004 Kassab, A., Gupta, I., & Al Moustafa, A. E. (2023, March). Role of E2F transcription factor in Oral cancer: Recent Insight and Advancements. In Seminars in Cancer Biology. Academic Press. 1044-579X https://www.sciencedirect.com/science/article/pii/S1044579X23000378 http://hdl.handle.net/10576/42577 28-41 92 1096-3650 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | E2F Oral cancer Transcription factors HPV Ageing Therapeutic targets |
| dc.title.none.fl_str_mv | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and differentiation, mainly in a cell cycle-dependent manner. E2F activity is frequently controlled via the retinoblastoma protein (pRb), cyclins, p53 and the ubiquitin-proteasome pathway. Additionally, genetic or epigenetic changes result in the deregulation of E2F family genes expression altering S phase entry and apoptosis, an important hallmark for the onset and development of cancer. Although studies reveal E2Fs to be involved in several human malignancies, the mechanisms underlying the role of E2Fs in oral cancer lies nascent and needs further investigations. This review focuses on the role of E2Fs in oral cancer and the etiological factors regulating E2Fs activity, which in turn transcriptionally control the expression of their target genes, thus contributing to cell proliferation, metastasis, and drug/therapy resistance. Further, we will discuss therapeutic strategies for E2Fs, which may prevent oral tumor growth, metastasis, and drug resistance. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_b91c6ec087615adeda25ff3572729dc1 |
| identifier_str_mv | Kassab, A., Gupta, I., & Al Moustafa, A. E. (2023, March). Role of E2F transcription factor in Oral cancer: Recent Insight and Advancements. In Seminars in Cancer Biology. Academic Press. 1044-579X 28-41 92 1096-3650 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/42577 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Role of E2F transcription factor in oral cancer: Recent insight and advancementsAmal, KassabGupta, IshitaMoustafa, Ala-Eddin AlE2FOral cancerTranscription factorsHPVAgeingTherapeutic targetsThe family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and differentiation, mainly in a cell cycle-dependent manner. E2F activity is frequently controlled via the retinoblastoma protein (pRb), cyclins, p53 and the ubiquitin-proteasome pathway. Additionally, genetic or epigenetic changes result in the deregulation of E2F family genes expression altering S phase entry and apoptosis, an important hallmark for the onset and development of cancer. Although studies reveal E2Fs to be involved in several human malignancies, the mechanisms underlying the role of E2Fs in oral cancer lies nascent and needs further investigations. This review focuses on the role of E2Fs in oral cancer and the etiological factors regulating E2Fs activity, which in turn transcriptionally control the expression of their target genes, thus contributing to cell proliferation, metastasis, and drug/therapy resistance. Further, we will discuss therapeutic strategies for E2Fs, which may prevent oral tumor growth, metastasis, and drug resistance.Elsevier2023-05-11T06:15:14Z2023-03-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.semcancer.2023.03.004Kassab, A., Gupta, I., & Al Moustafa, A. E. (2023, March). Role of E2F transcription factor in Oral cancer: Recent Insight and Advancements. In Seminars in Cancer Biology. Academic Press.1044-579Xhttps://www.sciencedirect.com/science/article/pii/S1044579X23000378http://hdl.handle.net/10576/4257728-41921096-3650enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/425772024-07-23T13:53:09Z |
| spellingShingle | Role of E2F transcription factor in oral cancer: Recent insight and advancements Amal, Kassab E2F Oral cancer Transcription factors HPV Ageing Therapeutic targets |
| status_str | publishedVersion |
| title | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| title_full | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| title_fullStr | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| title_full_unstemmed | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| title_short | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| title_sort | Role of E2F transcription factor in oral cancer: Recent insight and advancements |
| topic | E2F Oral cancer Transcription factors HPV Ageing Therapeutic targets |
| url | http://dx.doi.org/10.1016/j.semcancer.2023.03.004 https://www.sciencedirect.com/science/article/pii/S1044579X23000378 http://hdl.handle.net/10576/42577 |