Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts
IntroductionOsteoporosis, a significant public health concern, affects millions of adult women globally, leading to increased morbidity and fracture risk. Antidepressant use, prevalent in this demographic, is suggested to influence bone mineral density (BMD), yet evidence remains limited across anti...
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| التنسيق: | article |
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2025
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| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.jad.2024.10.114 https://www.sciencedirect.com/science/article/pii/S0165032724018081 http://hdl.handle.net/10576/64366 |
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| _version_ | 1857415085840924672 |
|---|---|
| author | Rajha, Humam Emad |
| author2 | Abdelaal, Reem Charfi, Khouloud Alemadi, Aisha O. Al-Sheraim, Alyaa S. Al-Maadid, Mubarak A. Louati, Youssef Doi, Suhail Khaled, Salma M. |
| author2_role | author author author author author author author author |
| author_facet | Rajha, Humam Emad Abdelaal, Reem Charfi, Khouloud Alemadi, Aisha O. Al-Sheraim, Alyaa S. Al-Maadid, Mubarak A. Louati, Youssef Doi, Suhail Khaled, Salma M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Rajha, Humam Emad Abdelaal, Reem Charfi, Khouloud Alemadi, Aisha O. Al-Sheraim, Alyaa S. Al-Maadid, Mubarak A. Louati, Youssef Doi, Suhail Khaled, Salma M. |
| dc.date.none.fl_str_mv | 2025-04-22T05:23:22Z 2025-01-15 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.jad.2024.10.114 01650327 https://www.sciencedirect.com/science/article/pii/S0165032724018081 http://hdl.handle.net/10576/64366 1223-1232 369 1573-2517 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Osteoporosis Fractures Bone mineral density (BMD) Major Depressive Disorder Antidepressants National Health and Nutrition Examination Survey (NHANES) Women |
| dc.title.none.fl_str_mv | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | IntroductionOsteoporosis, a significant public health concern, affects millions of adult women globally, leading to increased morbidity and fracture risk. Antidepressant use, prevalent in this demographic, is suggested to influence bone mineral density (BMD), yet evidence remains limited across antidepressant classes. Objective/aimWe investigated the association between antidepressant use and osteoporosis in a representative sample of adult women in the United States, focusing on different classes of antidepressants and their potential associations with BMD and fracture risk. MethodsWe conducted a cross-sectional analysis using data from ten cohorts of the National Health and Nutrition Examination Survey (NHANES) spanning 1999–2000 to 2017–2020. The sample included adult women, with data collected on antidepressant use, BMD scores, and reported fractures. Statistical models adjusted for potential confounders such as Major Depressive Disorder (MDD), age, physical activity, and comorbidities. ResultsAntidepressant use was associated with a 44 % increase in the odds of osteoporosis. Phenylpiperazines showed the highest association, followed by miscellaneous antidepressants and tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) also demonstrated significant, though comparatively lower associations. The odds of fractures were elevated by 62 % among antidepressant users, particularly with phenylpiperazines and miscellaneous antidepressants. A dose-response analysis indicated that both the number and duration of antidepressants were associated with increased odds of osteoporosis. ConclusionOur findings underscore the need for heightened awareness of the adverse effects of antidepressants on bone health, particularly in adult women. Careful consideration is necessary when prescribing these medications, especially in populations at risk for osteoporosis and MDD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_baacc7d12231a933db9bb0781e460484 |
| identifier_str_mv | 01650327 1223-1232 369 1573-2517 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/64366 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohortsRajha, Humam EmadAbdelaal, ReemCharfi, KhouloudAlemadi, Aisha O.Al-Sheraim, Alyaa S.Al-Maadid, Mubarak A.Louati, YoussefDoi, SuhailKhaled, Salma M.OsteoporosisFracturesBone mineral density (BMD)Major Depressive DisorderAntidepressantsNational Health and Nutrition Examination Survey (NHANES)WomenIntroductionOsteoporosis, a significant public health concern, affects millions of adult women globally, leading to increased morbidity and fracture risk. Antidepressant use, prevalent in this demographic, is suggested to influence bone mineral density (BMD), yet evidence remains limited across antidepressant classes. Objective/aimWe investigated the association between antidepressant use and osteoporosis in a representative sample of adult women in the United States, focusing on different classes of antidepressants and their potential associations with BMD and fracture risk. MethodsWe conducted a cross-sectional analysis using data from ten cohorts of the National Health and Nutrition Examination Survey (NHANES) spanning 1999–2000 to 2017–2020. The sample included adult women, with data collected on antidepressant use, BMD scores, and reported fractures. Statistical models adjusted for potential confounders such as Major Depressive Disorder (MDD), age, physical activity, and comorbidities. ResultsAntidepressant use was associated with a 44 % increase in the odds of osteoporosis. Phenylpiperazines showed the highest association, followed by miscellaneous antidepressants and tricyclic antidepressants (TCAs). Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) also demonstrated significant, though comparatively lower associations. The odds of fractures were elevated by 62 % among antidepressant users, particularly with phenylpiperazines and miscellaneous antidepressants. A dose-response analysis indicated that both the number and duration of antidepressants were associated with increased odds of osteoporosis. ConclusionOur findings underscore the need for heightened awareness of the adverse effects of antidepressants on bone health, particularly in adult women. Careful consideration is necessary when prescribing these medications, especially in populations at risk for osteoporosis and MDD.Elsevier2025-04-22T05:23:22Z2025-01-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jad.2024.10.11401650327https://www.sciencedirect.com/science/article/pii/S0165032724018081http://hdl.handle.net/10576/643661223-12323691573-2517enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/643662025-04-22T19:06:54Z |
| spellingShingle | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts Rajha, Humam Emad Osteoporosis Fractures Bone mineral density (BMD) Major Depressive Disorder Antidepressants National Health and Nutrition Examination Survey (NHANES) Women |
| status_str | publishedVersion |
| title | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| title_full | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| title_fullStr | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| title_full_unstemmed | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| title_short | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| title_sort | Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts |
| topic | Osteoporosis Fractures Bone mineral density (BMD) Major Depressive Disorder Antidepressants National Health and Nutrition Examination Survey (NHANES) Women |
| url | http://dx.doi.org/10.1016/j.jad.2024.10.114 https://www.sciencedirect.com/science/article/pii/S0165032724018081 http://hdl.handle.net/10576/64366 |