Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study

Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study

ObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with t...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Hiam, Chemaitelly (author)
مؤلفون آخرون: Faust, Jeremy Samuel (author), Krumholz, Harlan M. (author), Ayoub, Houssein H. (author), Tang, Patrick (author), Coyle, Peter (author), Yassine, Hadi M. (author), Al Thani, Asmaa A. (author), Al-Khatib, Hebah A. (author), Hasan, Mohammad R. (author), Al-Kanaani, Zaina (author), Al-Kuwari, Einas (author), Jeremijenko, Andrew (author), Kaleeckal, Anvar Hassan (author), Latif, Ali Nizar (author), Shaik, Riyazuddin Mohammad (author), Abdul-Rahim, Hanan F. (author), Nasrallah, Gheyath K. (author), Al-Kuwari, Mohamed Ghaith (author), Butt, Adeel A. (author), Al-Romaihi, Hamad Eid (author), Al-Thani, Mohamed H. (author), Al-Khal, Abdullatif (author), Bertollini, Roberto (author), Abu-Raddad, Laith J. (author)
التنسيق: article
منشور في: 2023
الموضوعات:
COVID-19
Acute infection
Immunity
Death
Long COVID
Cohort study
Epidemiology
الوصول للمادة أونلاين:http://dx.doi.org/10.1016/j.ijid.2023.09.005
https://www.sciencedirect.com/science/article/pii/S1201971223007191
http://hdl.handle.net/10576/49028
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الوصف
الملخص:ObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.

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