Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
ObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with t...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.ijid.2023.09.005 https://www.sciencedirect.com/science/article/pii/S1201971223007191 http://hdl.handle.net/10576/49028 |
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| _version_ | 1857415087450488832 |
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| author | Hiam, Chemaitelly |
| author2 | Faust, Jeremy Samuel Krumholz, Harlan M. Ayoub, Houssein H. Tang, Patrick Coyle, Peter Yassine, Hadi M. Al Thani, Asmaa A. Al-Khatib, Hebah A. Hasan, Mohammad R. Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Hiam, Chemaitelly Faust, Jeremy Samuel Krumholz, Harlan M. Ayoub, Houssein H. Tang, Patrick Coyle, Peter Yassine, Hadi M. Al Thani, Asmaa A. Al-Khatib, Hebah A. Hasan, Mohammad R. Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Hiam, Chemaitelly Faust, Jeremy Samuel Krumholz, Harlan M. Ayoub, Houssein H. Tang, Patrick Coyle, Peter Yassine, Hadi M. Al Thani, Asmaa A. Al-Khatib, Hebah A. Hasan, Mohammad R. Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. |
| dc.date.none.fl_str_mv | 2023-11-05T11:00:47Z 2023-11-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijid.2023.09.005 12019712 https://www.sciencedirect.com/science/article/pii/S1201971223007191 http://hdl.handle.net/10576/49028 81-90 136 1878-3511 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | COVID-19 Acute infection Immunity Death Long COVID Cohort study Epidemiology |
| dc.title.none.fl_str_mv | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_bf7e3ce5da99cb68df158af024924d16 |
| identifier_str_mv | 12019712 81-90 136 1878-3511 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/49028 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort studyHiam, ChemaitellyFaust, Jeremy SamuelKrumholz, Harlan M.Ayoub, Houssein H.Tang, PatrickCoyle, PeterYassine, Hadi M.Al Thani, Asmaa A.Al-Khatib, Hebah A.Hasan, Mohammad R.Al-Kanaani, ZainaAl-Kuwari, EinasJeremijenko, AndrewKaleeckal, Anvar HassanLatif, Ali NizarShaik, Riyazuddin MohammadAbdul-Rahim, Hanan F.Nasrallah, Gheyath K.Al-Kuwari, Mohamed GhaithButt, Adeel A.Al-Romaihi, Hamad EidAl-Thani, Mohamed H.Al-Khal, AbdullatifBertollini, RobertoAbu-Raddad, Laith J.COVID-19Acute infectionImmunityDeathLong COVIDCohort studyEpidemiologyObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.The Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core (both at Weill Cornell Medicine-Qatar), Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, and Qatar University Biomedical Research Center.Elsevier2023-11-05T11:00:47Z2023-11-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijid.2023.09.00512019712https://www.sciencedirect.com/science/article/pii/S1201971223007191http://hdl.handle.net/10576/4902881-901361878-3511enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/490282024-07-23T15:51:51Z |
| spellingShingle | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study Hiam, Chemaitelly COVID-19 Acute infection Immunity Death Long COVID Cohort study Epidemiology |
| status_str | publishedVersion |
| title | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_full | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_fullStr | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_full_unstemmed | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_short | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| title_sort | Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study |
| topic | COVID-19 Acute infection Immunity Death Long COVID Cohort study Epidemiology |
| url | http://dx.doi.org/10.1016/j.ijid.2023.09.005 https://www.sciencedirect.com/science/article/pii/S1201971223007191 http://hdl.handle.net/10576/49028 |