Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar
ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors attending Hamad Medical Corporation. A total of 1,948 sera were tested for anti-W...
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2020
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| Online Access: | http://dx.doi.org/10.1016/j.ijid.2020.11.175 https://www.sciencedirect.com/science/article/pii/S1201971220324875?v=s5 http://hdl.handle.net/10576/17123 |
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| _version_ | 1857415087520743424 |
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| author | Soha R., Dargham |
| author2 | Al-Sadeq, Duaa W. Yassine, Hadi M. Ahmed, Muna Kunhipurayil, Hasna Humphrey, John M. Abu-Raddad, Laith J. Nasrallah, Gheyath K. |
| author2_role | author author author author author author author |
| author_facet | Soha R., Dargham Al-Sadeq, Duaa W. Yassine, Hadi M. Ahmed, Muna Kunhipurayil, Hasna Humphrey, John M. Abu-Raddad, Laith J. Nasrallah, Gheyath K. |
| author_role | author |
| dc.creator.none.fl_str_mv | Soha R., Dargham Al-Sadeq, Duaa W. Yassine, Hadi M. Ahmed, Muna Kunhipurayil, Hasna Humphrey, John M. Abu-Raddad, Laith J. Nasrallah, Gheyath K. |
| dc.date.none.fl_str_mv | 2020-11-29T05:10:46Z 2020-11-25 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijid.2020.11.175 Dargham SR, Al-Sadeq DW, Yassine HM, Ahmed M, Kunhipurayil H, Humphrey JM, Abu-Raddad LJ, Nasrallah GK, Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar, International Journal of Infectious Diseases (2020), doi: https://doi.org/10.1016/j.ijid.2020.11.175 1201-9712 https://www.sciencedirect.com/science/article/pii/S1201971220324875?v=s5 http://hdl.handle.net/10576/17123 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Arbovirus prevalence Vector-borne disease Mosquito West Nile Fever Zoonosis Qatar |
| dc.title.none.fl_str_mv | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors attending Hamad Medical Corporation. A total of 1,948 sera were tested for anti-WNV antibodies using Serion ELISA classic IgG and IgM kits. ResultsOverall, seroprevalence estimates of WNV-specific IgG and IgM antibodies were 10.4% and 3.3%, respectively. Country-specific WNV-specific IgG seroprevalence was estimated to be 37.0% (34/92) in Sudanese, 33.0% in Egyptians (66/200), 13.0% (26/200) in Indians, 10.6% (11/104) in Iranians, 10.2% (14/137) in Yemenis, 9.2% (18/195) in Pakistanis, 7.0% ( 14/199) in Jordanians, 5.4% (6/111) in Filipinos, 2.5% (5/200) in Palestinians, 2.5% (5/200) in Syrians, 1.5% (3/200) in Qataris, and 0.9% (1/110) in Lebanese. Seroprevalence of WNV-specific IgM was lowest in Iranians (0/77), Lebanese (0/108), and Filipinos (0/107) at 0.0%, and was highest in Sudanese at 10.0% (8/80). While there seemed to be apparent trends in the prevalence of WNV-IgM and WNV-IgG antibodies, none of these trends were found statistically significant. ConclusionThe findings support the circulation of WNV in human populations in the different countries of the MENA region. Seroprevalence was highest in Sudanese and Egyptians and lowest in Qataris and nationals of the Levant. The findings call for further animal, vector, and human studies, such as studying the actual prevalence of the viral RNA in blood donors to assess risk of viral transmission through blood donation and for a better characterization of the epidemiology of this infection in this part of the world. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_cf4ddadc01debcd6ae3ee4abae699ce0 |
| identifier_str_mv | Dargham SR, Al-Sadeq DW, Yassine HM, Ahmed M, Kunhipurayil H, Humphrey JM, Abu-Raddad LJ, Nasrallah GK, Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar, International Journal of Infectious Diseases (2020), doi: https://doi.org/10.1016/j.ijid.2020.11.175 1201-9712 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/17123 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in QatarSoha R., DarghamAl-Sadeq, Duaa W.Yassine, Hadi M.Ahmed, MunaKunhipurayil, HasnaHumphrey, John M.Abu-Raddad, Laith J.Nasrallah, Gheyath K.ArbovirusprevalenceVector-borne diseaseMosquitoWest Nile FeverZoonosisQatarObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors attending Hamad Medical Corporation. A total of 1,948 sera were tested for anti-WNV antibodies using Serion ELISA classic IgG and IgM kits. ResultsOverall, seroprevalence estimates of WNV-specific IgG and IgM antibodies were 10.4% and 3.3%, respectively. Country-specific WNV-specific IgG seroprevalence was estimated to be 37.0% (34/92) in Sudanese, 33.0% in Egyptians (66/200), 13.0% (26/200) in Indians, 10.6% (11/104) in Iranians, 10.2% (14/137) in Yemenis, 9.2% (18/195) in Pakistanis, 7.0% ( 14/199) in Jordanians, 5.4% (6/111) in Filipinos, 2.5% (5/200) in Palestinians, 2.5% (5/200) in Syrians, 1.5% (3/200) in Qataris, and 0.9% (1/110) in Lebanese. Seroprevalence of WNV-specific IgM was lowest in Iranians (0/77), Lebanese (0/108), and Filipinos (0/107) at 0.0%, and was highest in Sudanese at 10.0% (8/80). While there seemed to be apparent trends in the prevalence of WNV-IgM and WNV-IgG antibodies, none of these trends were found statistically significant. ConclusionThe findings support the circulation of WNV in human populations in the different countries of the MENA region. Seroprevalence was highest in Sudanese and Egyptians and lowest in Qataris and nationals of the Levant. The findings call for further animal, vector, and human studies, such as studying the actual prevalence of the viral RNA in blood donors to assess risk of viral transmission through blood donation and for a better characterization of the epidemiology of this infection in this part of the world.Qatar University internal grant (QUCG-CHS-19/20-1), Qatar National Research Fund (UREP20-020-3-003 and NPRP 9-040-3-008), and the Biomedical Research Program at Weill Cornell Medicine-Qatar.Elsevier2020-11-29T05:10:46Z2020-11-25Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijid.2020.11.175Dargham SR, Al-Sadeq DW, Yassine HM, Ahmed M, Kunhipurayil H, Humphrey JM, Abu-Raddad LJ, Nasrallah GK, Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar, International Journal of Infectious Diseases (2020), doi: https://doi.org/10.1016/j.ijid.2020.11.1751201-9712https://www.sciencedirect.com/science/article/pii/S1201971220324875?v=s5http://hdl.handle.net/10576/17123enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/171232024-07-23T11:23:10Z |
| spellingShingle | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar Soha R., Dargham Arbovirus prevalence Vector-borne disease Mosquito West Nile Fever Zoonosis Qatar |
| status_str | publishedVersion |
| title | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| title_full | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| title_fullStr | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| title_full_unstemmed | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| title_short | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| title_sort | Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar |
| topic | Arbovirus prevalence Vector-borne disease Mosquito West Nile Fever Zoonosis Qatar |
| url | http://dx.doi.org/10.1016/j.ijid.2020.11.175 https://www.sciencedirect.com/science/article/pii/S1201971220324875?v=s5 http://hdl.handle.net/10576/17123 |