Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). We investigated...

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Bibliographic Details
Main Author: Jinit, Masania (author)
Other Authors: Wijten, Patrick (author), Keipert, Susanne (author), Ost, Mario (author), Klaus, Susanne (author), Rabbani, Naila (author), Thornalley, Paul J. (author)
Format: article
Published: 2023
Subjects:
Aging
Uncoupling protein 1
Skeletal muscle
Protein glycation
Methylglyoxal
Proteomics
Online Access:http://dx.doi.org/10.1016/j.redox.2022.102574
https://www.sciencedirect.com/science/article/pii/S2213231722003469
http://hdl.handle.net/10576/44666
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http://dx.doi.org/10.1016/j.redox.2022.102574
https://www.sciencedirect.com/science/article/pii/S2213231722003469
http://hdl.handle.net/10576/44666

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