Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE)
ObjectivesPatients with systemic lupus erythematosus (SLE) are at higher risk for coronary artery disease (CAD) particularly at a younger age. We sought to determine the effect of risk factors on the prevalence of CAD in age stratified hospitalized patients with SLE. MethodsThe National Inpatient Sa...
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2020
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| Online Access: | http://dx.doi.org/10.1016/j.ijchy.2020.100056 https://www.sciencedirect.com/science/article/pii/S2590086220300331 http://hdl.handle.net/10576/44623 |
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| _version_ | 1857415086521450496 |
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| author | Dennis J., Levinson |
| author2 | Abugroun, Ashraf Daoud, Hussein Abdel-Rahman, Manar |
| author2_role | author author author |
| author_facet | Dennis J., Levinson Abugroun, Ashraf Daoud, Hussein Abdel-Rahman, Manar |
| author_role | author |
| dc.creator.none.fl_str_mv | Dennis J., Levinson Abugroun, Ashraf Daoud, Hussein Abdel-Rahman, Manar |
| dc.date.none.fl_str_mv | 2020-12-31 2023-06-21T05:05:37Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ijchy.2020.100056 25900862 https://www.sciencedirect.com/science/article/pii/S2590086220300331 http://hdl.handle.net/10576/44623 7 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | SLE Lupus Coronary artery disease Risk factors |
| dc.title.none.fl_str_mv | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ObjectivesPatients with systemic lupus erythematosus (SLE) are at higher risk for coronary artery disease (CAD) particularly at a younger age. We sought to determine the effect of risk factors on the prevalence of CAD in age stratified hospitalized patients with SLE. MethodsThe National Inpatient Sample (NIS) was queried for hospitalized patients with SLE during the years 2010–2015, and a control group without SLE. The study sample was stratified by age, 18–35 years, 36–55 years, and adults >55 years. The effect of SLE and traditional Framingham risk factors on the prevalence of CAD were assessed. Dominance analysis allowed for ranking of CAD risk factors in each age group. ResultsA total 167,466 patients were matched to an equal number of controls. 88.8% were women, 48.5% Caucasian and 29% African-American. In lupus patients 18–35 years prevalent risk factors included hyperlipidemia, hypertension, hypercoagulability and CKD. Diabetes and depression ranked least important. In middle and older patients, traditional risk factors were dominant. In adults >55 years the prevalence of CAD appears higher in Caucasians whereas in young patients 18–35 years, African Americans are dominant. ConclusionCAD in the young adult patient with SLE is represented predominately by an African-American population and it is dominated by a hypercoagulable state and a less significant role for diabetes. In the lupus cohort over 55 years, which is predominantly Caucasian, SLE specific factors are less significant. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_e2e1fc77f07868569f3e413b56dda413 |
| identifier_str_mv | 25900862 7 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/44623 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE)Dennis J., LevinsonAbugroun, AshrafDaoud, HusseinAbdel-Rahman, ManarSLELupusCoronary artery diseaseRisk factorsObjectivesPatients with systemic lupus erythematosus (SLE) are at higher risk for coronary artery disease (CAD) particularly at a younger age. We sought to determine the effect of risk factors on the prevalence of CAD in age stratified hospitalized patients with SLE. MethodsThe National Inpatient Sample (NIS) was queried for hospitalized patients with SLE during the years 2010–2015, and a control group without SLE. The study sample was stratified by age, 18–35 years, 36–55 years, and adults >55 years. The effect of SLE and traditional Framingham risk factors on the prevalence of CAD were assessed. Dominance analysis allowed for ranking of CAD risk factors in each age group. ResultsA total 167,466 patients were matched to an equal number of controls. 88.8% were women, 48.5% Caucasian and 29% African-American. In lupus patients 18–35 years prevalent risk factors included hyperlipidemia, hypertension, hypercoagulability and CKD. Diabetes and depression ranked least important. In middle and older patients, traditional risk factors were dominant. In adults >55 years the prevalence of CAD appears higher in Caucasians whereas in young patients 18–35 years, African Americans are dominant. ConclusionCAD in the young adult patient with SLE is represented predominately by an African-American population and it is dominated by a hypercoagulable state and a less significant role for diabetes. In the lupus cohort over 55 years, which is predominantly Caucasian, SLE specific factors are less significant.Elsevier2023-06-21T05:05:37Z2020-12-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ijchy.2020.10005625900862https://www.sciencedirect.com/science/article/pii/S2590086220300331http://hdl.handle.net/10576/446237enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/446232024-07-23T13:53:39Z |
| spellingShingle | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) Dennis J., Levinson SLE Lupus Coronary artery disease Risk factors |
| status_str | publishedVersion |
| title | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| title_full | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| title_fullStr | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| title_full_unstemmed | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| title_short | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| title_sort | Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) |
| topic | SLE Lupus Coronary artery disease Risk factors |
| url | http://dx.doi.org/10.1016/j.ijchy.2020.100056 https://www.sciencedirect.com/science/article/pii/S2590086220300331 http://hdl.handle.net/10576/44623 |