Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties
Inflammation is associated with the development and progression of a plethora of diseases including joint, metabolic, neurological, hepatic, and renal disorders. Sesamol, derived from the seeds of Sesamum indicum L., has received considerable attention due to its well-documented multipotent phytothe...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Format: | article |
| Published: |
2023
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1016/j.ejphar.2023.176163 https://www.sciencedirect.com/science/article/pii/S0014299923006775 http://hdl.handle.net/10576/50709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1857415083867504640 |
|---|---|
| author | Amin F., Majdalawieh |
| author2 | Ahari, Sogand H. Yousef, Sarah M. Nasrallah, Gheyath K. |
| author2_role | author author author |
| author_facet | Amin F., Majdalawieh Ahari, Sogand H. Yousef, Sarah M. Nasrallah, Gheyath K. |
| author_role | author |
| dc.creator.none.fl_str_mv | Amin F., Majdalawieh Ahari, Sogand H. Yousef, Sarah M. Nasrallah, Gheyath K. |
| dc.date.none.fl_str_mv | 2023-12-05 2024-01-14T08:32:08Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.ejphar.2023.176163 00142999 https://www.sciencedirect.com/science/article/pii/S0014299923006775 http://hdl.handle.net/10576/50709 960 1879-0712 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Sesamol Lignans Th1/Th2 balance Inflammation Cytokines Anti-inflammatory agents |
| dc.title.none.fl_str_mv | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Inflammation is associated with the development and progression of a plethora of diseases including joint, metabolic, neurological, hepatic, and renal disorders. Sesamol, derived from the seeds of Sesamum indicum L., has received considerable attention due to its well-documented multipotent phytotherapeutic effects, including its anti-inflammatory and immunomodulatory properties. However, to date, no comprehensive review has been established to highlight or summarize the anti-inflammatory and immunomodulatory properties of sesamol. Herein, we aim to address this gap in the literature by presenting a thorough review encapsulating evidence surrounding the range of inflammatory mediators and cytokines shown to be targeted by sesamol in modulating its anti-inflammatory actions against a range of inflammatory disorders. Additionally, evidence highlighting the role that sesamol has in modulating components of adaptive immunity including cellular immune responses and Th1/Th2 balance is underscored. Moreover, the molecular mechanisms and the signaling pathways underlying such effects are also highlighted. Findings indicate that this seemingly potent lignan mediates its anti-inflammatory actions, at least in part, via suppression of various pro-inflammatory cytokines like IL-1β and TNFα, and downregulation of a multitude of signaling pathways including NF-κB and MAPK. In conclusion, we anticipate that sesamol may be employed in future therapeutic regimens to aid in more effective drug development to alleviate immune-related and inflammatory conditions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_e3502430c4c592ce98e1fcddae313acf |
| identifier_str_mv | 00142999 960 1879-0712 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/50709 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory propertiesAmin F., MajdalawiehAhari, Sogand H.Yousef, Sarah M.Nasrallah, Gheyath K.SesamolLignansTh1/Th2 balanceInflammationCytokinesAnti-inflammatory agentsInflammation is associated with the development and progression of a plethora of diseases including joint, metabolic, neurological, hepatic, and renal disorders. Sesamol, derived from the seeds of Sesamum indicum L., has received considerable attention due to its well-documented multipotent phytotherapeutic effects, including its anti-inflammatory and immunomodulatory properties. However, to date, no comprehensive review has been established to highlight or summarize the anti-inflammatory and immunomodulatory properties of sesamol. Herein, we aim to address this gap in the literature by presenting a thorough review encapsulating evidence surrounding the range of inflammatory mediators and cytokines shown to be targeted by sesamol in modulating its anti-inflammatory actions against a range of inflammatory disorders. Additionally, evidence highlighting the role that sesamol has in modulating components of adaptive immunity including cellular immune responses and Th1/Th2 balance is underscored. Moreover, the molecular mechanisms and the signaling pathways underlying such effects are also highlighted. Findings indicate that this seemingly potent lignan mediates its anti-inflammatory actions, at least in part, via suppression of various pro-inflammatory cytokines like IL-1β and TNFα, and downregulation of a multitude of signaling pathways including NF-κB and MAPK. In conclusion, we anticipate that sesamol may be employed in future therapeutic regimens to aid in more effective drug development to alleviate immune-related and inflammatory conditions.Elsevier2024-01-14T08:32:08Z2023-12-05Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ejphar.2023.17616300142999https://www.sciencedirect.com/science/article/pii/S0014299923006775http://hdl.handle.net/10576/507099601879-0712enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/507092024-12-01T09:44:34Z |
| spellingShingle | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties Amin F., Majdalawieh Sesamol Lignans Th1/Th2 balance Inflammation Cytokines Anti-inflammatory agents |
| status_str | publishedVersion |
| title | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| title_full | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| title_fullStr | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| title_full_unstemmed | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| title_short | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| title_sort | Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties |
| topic | Sesamol Lignans Th1/Th2 balance Inflammation Cytokines Anti-inflammatory agents |
| url | http://dx.doi.org/10.1016/j.ejphar.2023.176163 https://www.sciencedirect.com/science/article/pii/S0014299923006775 http://hdl.handle.net/10576/50709 |