Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to their special properties, iron oxide, gold and silver nanoparticles (NPs) coul...
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2021
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| Online Access: | http://dx.doi.org/10.1016/j.nano.2021.102433 https://www.sciencedirect.com/science/article/pii/S1549963421000769 http://hdl.handle.net/10576/44650 |
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| _version_ | 1857415085927956480 |
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| author | Nour K., Younis |
| author2 | Ghoubaira, Joseph A. Bassil, Emmanuel P. Tantawi, Houda N. Eid, Ali H. |
| author2_role | author author author author |
| author_facet | Nour K., Younis Ghoubaira, Joseph A. Bassil, Emmanuel P. Tantawi, Houda N. Eid, Ali H. |
| author_role | author |
| dc.creator.none.fl_str_mv | Nour K., Younis Ghoubaira, Joseph A. Bassil, Emmanuel P. Tantawi, Houda N. Eid, Ali H. |
| dc.date.none.fl_str_mv | 2021-08-31 2023-06-21T08:52:56Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.nano.2021.102433 15499634 https://www.sciencedirect.com/science/article/pii/S1549963421000769 http://hdl.handle.net/10576/44650 36 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cardiovascular disease Nanomedicine Silver nanoparticles Iron oxide nanoparticles Gold nanoparticles Atherosclerosis |
| dc.title.none.fl_str_mv | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to their special properties, iron oxide, gold and silver nanoparticles (NPs) could exert various effects in the management and treatment of CVD. The role of iron oxide NPs in the detection and identification of atherosclerotic plaques is receiving increased attention. Moreover, these NPs enhance targeted stem cell delivery, thereby potentiating the regenerative capacity at the injured sites. In addition to their antioxidative and antihypertrophic capacities, gold NPs have also been shown to be useful in the identification of plaques and recognition of inflammatory markers. Contrary to first reports suggestive of their cardio-vasculoprotective role, silver NPs now appear to exert negative effects on the cardiovascular system. Indeed, these NPs appear to negatively modulate inflammation and cholesterol uptake, both of which exacerbate atherosclerosis. Moreover, silver NPs may precipitate bradycardia, conduction block and sudden cardiac death. In this review, we dissect the cellular responses and toxicity profiles of these NPs from various perspectives including cellular and molecular ones. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_e9d3915ec81809697eca2f599408fd79 |
| identifier_str_mv | 15499634 36 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/44650 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseasesNour K., YounisGhoubaira, Joseph A.Bassil, Emmanuel P.Tantawi, Houda N.Eid, Ali H.Cardiovascular diseaseNanomedicineSilver nanoparticlesIron oxide nanoparticlesGold nanoparticlesAtherosclerosisCardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to their special properties, iron oxide, gold and silver nanoparticles (NPs) could exert various effects in the management and treatment of CVD. The role of iron oxide NPs in the detection and identification of atherosclerotic plaques is receiving increased attention. Moreover, these NPs enhance targeted stem cell delivery, thereby potentiating the regenerative capacity at the injured sites. In addition to their antioxidative and antihypertrophic capacities, gold NPs have also been shown to be useful in the identification of plaques and recognition of inflammatory markers. Contrary to first reports suggestive of their cardio-vasculoprotective role, silver NPs now appear to exert negative effects on the cardiovascular system. Indeed, these NPs appear to negatively modulate inflammation and cholesterol uptake, both of which exacerbate atherosclerosis. Moreover, silver NPs may precipitate bradycardia, conduction block and sudden cardiac death. In this review, we dissect the cellular responses and toxicity profiles of these NPs from various perspectives including cellular and molecular ones.Elsevier2023-06-21T08:52:56Z2021-08-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.nano.2021.10243315499634https://www.sciencedirect.com/science/article/pii/S1549963421000769http://hdl.handle.net/10576/4465036enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/446502024-07-23T13:53:41Z |
| spellingShingle | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases Nour K., Younis Cardiovascular disease Nanomedicine Silver nanoparticles Iron oxide nanoparticles Gold nanoparticles Atherosclerosis |
| status_str | publishedVersion |
| title | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| title_full | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| title_fullStr | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| title_full_unstemmed | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| title_short | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| title_sort | Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases |
| topic | Cardiovascular disease Nanomedicine Silver nanoparticles Iron oxide nanoparticles Gold nanoparticles Atherosclerosis |
| url | http://dx.doi.org/10.1016/j.nano.2021.102433 https://www.sciencedirect.com/science/article/pii/S1549963421000769 http://hdl.handle.net/10576/44650 |