The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports
The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP has recently gained attention due to increasing seizures and involvement in...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2024
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.neuro.2024.06.014 https://www.sciencedirect.com/science/article/pii/S0161813X2400069X http://hdl.handle.net/10576/59331 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1857415085876576256 |
|---|---|
| author | Marta, Bassi |
| author2 | Bilel, Sabrine Tirri, Micaela Corli, Giorgia Di Rosa, Fabiana Gregori, Adolfo Alkilany, Alaaldin M. Rachid, Ousama Roda, Elisa De Luca, Fabrizio Papa, Pietro Buscaglia, Eleonora Zauli, Giorgio Locatelli, Carlo Alessandro Marti, Matteo |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Marta, Bassi Bilel, Sabrine Tirri, Micaela Corli, Giorgia Di Rosa, Fabiana Gregori, Adolfo Alkilany, Alaaldin M. Rachid, Ousama Roda, Elisa De Luca, Fabrizio Papa, Pietro Buscaglia, Eleonora Zauli, Giorgio Locatelli, Carlo Alessandro Marti, Matteo |
| author_role | author |
| dc.creator.none.fl_str_mv | Marta, Bassi Bilel, Sabrine Tirri, Micaela Corli, Giorgia Di Rosa, Fabiana Gregori, Adolfo Alkilany, Alaaldin M. Rachid, Ousama Roda, Elisa De Luca, Fabrizio Papa, Pietro Buscaglia, Eleonora Zauli, Giorgio Locatelli, Carlo Alessandro Marti, Matteo |
| dc.date.none.fl_str_mv | 2024-09-26T08:28:10Z 2024-06-30 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.neuro.2024.06.014 Bassi, M., Bilel, S., Tirri, M., Corli, G., Di Rosa, F., Gregori, A., ... & Marti, M. (2024). The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports. NeuroToxicology, 103, 230-255. 0161-813X https://www.sciencedirect.com/science/article/pii/S0161813X2400069X http://hdl.handle.net/10576/59331 230-255 103 1872-9711 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone 3,4-methylenedioxypyrovalerone Synthetic cathinone Behaviour Aggressivity Cardiovascular effect ADMET prediction Human intoxication |
| dc.title.none.fl_str_mv | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP has recently gained attention due to increasing seizures and involvement in human intoxications which occurred in Europe and Italy in the last years, but currently there is a lack of information about its pharmaco-toxicological effects. With the aim at filling this gap, the present study is endeavoured to (i) evaluate the effects of acute administration of MDPHP (0.01–20 mg/kg; i.p.) on behaviour, cardiorespiratory and cardiovascular parameters in CD-1 male mice, comparing them to those observed after administration of MDPV; (ii) predict the ADMET profile of the two analogues using the Plus ADMET Predictor®; (iii) present clinical data related to MDPHP and MDPV-induced intoxications recorded between 2011 and 2023 by the Pavia Poison Control Centre (PCC) − National Toxicology Information Centre (Istituti Clinici Scientifici Maugeri, IRCCS Pavia, Italy). Our results substantiated that MDPHP and MDPV similarly affect sensorimotor and behavioural responses in mice, importantly increased locomotion and induced aggressive behaviour, and, at higher dosage, increased heart rate and blood pressure. These findings are in line with those observed in humans, revealing severe toxidromes typically characterized by Central Nervous System (CNS) alterations (behavioural/neuropsychiatric symptoms), including psychomotor agitation and aggressiveness, cardiovascular and respiratory disorders (e.g. tachycardia, hypertension, dyspnoea), and other peripheral symptoms (e.g. hyperthermia, acidosis, rhabdomyolysis). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_f3875a5e4d0d02483783d5922c03c722 |
| identifier_str_mv | Bassi, M., Bilel, S., Tirri, M., Corli, G., Di Rosa, F., Gregori, A., ... & Marti, M. (2024). The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports. NeuroToxicology, 103, 230-255. 0161-813X 230-255 103 1872-9711 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/59331 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reportsMarta, BassiBilel, SabrineTirri, MicaelaCorli, GiorgiaDi Rosa, FabianaGregori, AdolfoAlkilany, Alaaldin M.Rachid, OusamaRoda, ElisaDe Luca, FabrizioPapa, PietroBuscaglia, EleonoraZauli, GiorgioLocatelli, Carlo AlessandroMarti, Matteo3,4-methylenedioxy-alpha-pyrrolidinohexanophenone3,4-methylenedioxypyrovaleroneSynthetic cathinoneBehaviourAggressivityCardiovascular effectADMET predictionHuman intoxicationThe 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP has recently gained attention due to increasing seizures and involvement in human intoxications which occurred in Europe and Italy in the last years, but currently there is a lack of information about its pharmaco-toxicological effects. With the aim at filling this gap, the present study is endeavoured to (i) evaluate the effects of acute administration of MDPHP (0.01–20 mg/kg; i.p.) on behaviour, cardiorespiratory and cardiovascular parameters in CD-1 male mice, comparing them to those observed after administration of MDPV; (ii) predict the ADMET profile of the two analogues using the Plus ADMET Predictor®; (iii) present clinical data related to MDPHP and MDPV-induced intoxications recorded between 2011 and 2023 by the Pavia Poison Control Centre (PCC) − National Toxicology Information Centre (Istituti Clinici Scientifici Maugeri, IRCCS Pavia, Italy). Our results substantiated that MDPHP and MDPV similarly affect sensorimotor and behavioural responses in mice, importantly increased locomotion and induced aggressive behaviour, and, at higher dosage, increased heart rate and blood pressure. These findings are in line with those observed in humans, revealing severe toxidromes typically characterized by Central Nervous System (CNS) alterations (behavioural/neuropsychiatric symptoms), including psychomotor agitation and aggressiveness, cardiovascular and respiratory disorders (e.g. tachycardia, hypertension, dyspnoea), and other peripheral symptoms (e.g. hyperthermia, acidosis, rhabdomyolysis).This research has been funded by the Anti-Drug Policies Department, Presidency of the Council of Ministers, Italy (project: \u201CEffects of NPS: development of a multicentre research for the information enhancement of the Early Warning System\u201D to M. Marti; project: \u201CImplementation of the identification and study of the effects of NPS: Development of a multicentric research to strengthen the database of the National Monitoring Centre for Drug Addiction and the Early Warning System\u201D to M. Marti), local funds from the University of Ferrara (FAR 2022, FAR 2023 to M. Marti).Elsevier2024-09-26T08:28:10Z2024-06-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.neuro.2024.06.014Bassi, M., Bilel, S., Tirri, M., Corli, G., Di Rosa, F., Gregori, A., ... & Marti, M. (2024). The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports. NeuroToxicology, 103, 230-255.0161-813Xhttps://www.sciencedirect.com/science/article/pii/S0161813X2400069Xhttp://hdl.handle.net/10576/59331230-2551031872-9711enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/593312024-09-26T19:06:13Z |
| spellingShingle | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports Marta, Bassi 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone 3,4-methylenedioxypyrovalerone Synthetic cathinone Behaviour Aggressivity Cardiovascular effect ADMET prediction Human intoxication |
| status_str | publishedVersion |
| title | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| title_full | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| title_fullStr | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| title_full_unstemmed | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| title_short | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| title_sort | The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports |
| topic | 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone 3,4-methylenedioxypyrovalerone Synthetic cathinone Behaviour Aggressivity Cardiovascular effect ADMET prediction Human intoxication |
| url | http://dx.doi.org/10.1016/j.neuro.2024.06.014 https://www.sciencedirect.com/science/article/pii/S0161813X2400069X http://hdl.handle.net/10576/59331 |