Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru
BackgroundThe role of maternal stress levels on mothers’ mental health and fetal growth has been previously studied. However, the evidence linking cortisol exposure during pregnancy to growth outcomes in infants is sparsely available from lower and middle-income countries. We aim to investigate the...
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2023
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| Online Access: | http://dx.doi.org/10.1016/j.lansea.2023.100196 https://www.sciencedirect.com/science/article/pii/S2772368223000562 http://hdl.handle.net/10576/52536 |
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| _version_ | 1857415085920616448 |
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| author | Prafulla, Shriyan |
| author2 | Sudhir, Paulomi van Schayck, Onno C.P. Babu, Giridhara R. |
| author2_role | author author author |
| author_facet | Prafulla, Shriyan Sudhir, Paulomi van Schayck, Onno C.P. Babu, Giridhara R. |
| author_role | author |
| dc.creator.none.fl_str_mv | Prafulla, Shriyan Sudhir, Paulomi van Schayck, Onno C.P. Babu, Giridhara R. |
| dc.date.none.fl_str_mv | 2023-07-31 2024-03-03T03:50:53Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.lansea.2023.100196 27723682 https://www.sciencedirect.com/science/article/pii/S2772368223000562 http://hdl.handle.net/10576/52536 14 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pregnancy Serum cortisol Fetal growth Stress Biomarker Anthropometry |
| dc.title.none.fl_str_mv | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | BackgroundThe role of maternal stress levels on mothers’ mental health and fetal growth has been previously studied. However, the evidence linking cortisol exposure during pregnancy to growth outcomes in infants is sparsely available from lower and middle-income countries. We aim to investigate the association of serum cortisol levels in pregnancy with infant birth outcomes and postpartum depressive symptoms in a public health facility in India. MethodsThe current study is a part of the maternal antecedents of adiposity and studying the transgenerational role of hyperglycemia and insulin (MAASTHI) prospective cohort. We assessed the relationship between maternal exposure to serum cortisol and adverse neonatal outcomes and postpartum depressive symptoms. Serum cortisol levels in stored blood samples were measured in 230 pregnant women as a biomarker for stress during pregnancy. Pregnant women between 18 and 45 years of age were recruited for the study, presenting at ≥14 weeks of gestation and providing voluntary written informed consent. The Edinburgh Postnatal Depression Scale assessed postpartum depressive symptoms, and detailed infant anthropometric measurements were carried out at birth. FindingsWe found that higher levels (>17.66 μg/L) are significantly associated with low birth weight (OR = 2.28; 95% CI 1.21–4.32) and lower weight for length (OR = 2.16; 95% CI 1.07–4.35). The odds of developing postpartum depressive symptoms in pregnant women with higher mean cortisol cut-off levels is 2.3-fold [OR: 2.33, 95% CI (1.17, 4.64)] compared than women with lower cortisol levels. No significant association was found between serum cortisol and infants' birth weight for gestational age, head circumference, the sum of skinfold thickness, and crown-rump length. InterpretationOur results support the hypothesis that higher maternal cortisol levels may adversely impact birth weight, weight for length in newborns, and postpartum depressive symptoms in mothers. FundingThis study was supported by the India Alliance Senior Fellowship [Grant No. IA/CPHS/20/1/505278] awarded to Giridhara R. Babu. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_f72d7c4a28b89422aeb6254a67d467ec |
| identifier_str_mv | 27723682 14 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/52536 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, BengaluruPrafulla, ShriyanSudhir, Paulomivan Schayck, Onno C.P.Babu, Giridhara R.PregnancySerum cortisolFetal growthStressBiomarkerAnthropometryBackgroundThe role of maternal stress levels on mothers’ mental health and fetal growth has been previously studied. However, the evidence linking cortisol exposure during pregnancy to growth outcomes in infants is sparsely available from lower and middle-income countries. We aim to investigate the association of serum cortisol levels in pregnancy with infant birth outcomes and postpartum depressive symptoms in a public health facility in India. MethodsThe current study is a part of the maternal antecedents of adiposity and studying the transgenerational role of hyperglycemia and insulin (MAASTHI) prospective cohort. We assessed the relationship between maternal exposure to serum cortisol and adverse neonatal outcomes and postpartum depressive symptoms. Serum cortisol levels in stored blood samples were measured in 230 pregnant women as a biomarker for stress during pregnancy. Pregnant women between 18 and 45 years of age were recruited for the study, presenting at ≥14 weeks of gestation and providing voluntary written informed consent. The Edinburgh Postnatal Depression Scale assessed postpartum depressive symptoms, and detailed infant anthropometric measurements were carried out at birth. FindingsWe found that higher levels (>17.66 μg/L) are significantly associated with low birth weight (OR = 2.28; 95% CI 1.21–4.32) and lower weight for length (OR = 2.16; 95% CI 1.07–4.35). The odds of developing postpartum depressive symptoms in pregnant women with higher mean cortisol cut-off levels is 2.3-fold [OR: 2.33, 95% CI (1.17, 4.64)] compared than women with lower cortisol levels. No significant association was found between serum cortisol and infants' birth weight for gestational age, head circumference, the sum of skinfold thickness, and crown-rump length. InterpretationOur results support the hypothesis that higher maternal cortisol levels may adversely impact birth weight, weight for length in newborns, and postpartum depressive symptoms in mothers. FundingThis study was supported by the India Alliance Senior Fellowship [Grant No. IA/CPHS/20/1/505278] awarded to Giridhara R. Babu.This work was supported by the Wellcome Trust DBT India Alliance Senior Fellowship [Grant No. IA/CPHS/20/1/505278] awarded to Giridhara R. Babu. The authors declare that they have no competing interests.Elsevier2024-03-03T03:50:53Z2023-07-31Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.lansea.2023.10019627723682https://www.sciencedirect.com/science/article/pii/S2772368223000562http://hdl.handle.net/10576/5253614enhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/525362024-07-23T15:52:57Z |
| spellingShingle | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru Prafulla, Shriyan Pregnancy Serum cortisol Fetal growth Stress Biomarker Anthropometry |
| status_str | publishedVersion |
| title | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| title_full | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| title_fullStr | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| title_full_unstemmed | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| title_short | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| title_sort | Association of high cortisol levels in pregnancy and altered fetal growth. Results from the MAASTHI, a prospective cohort study, Bengaluru |
| topic | Pregnancy Serum cortisol Fetal growth Stress Biomarker Anthropometry |
| url | http://dx.doi.org/10.1016/j.lansea.2023.100196 https://www.sciencedirect.com/science/article/pii/S2772368223000562 http://hdl.handle.net/10576/52536 |