Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers
Aerosolization is a non-invasive approach of delivering drugs for both localized and systemic effects, specifically pulmonary targeting. The aim of this study was to deliver trans-resveratrol (TR) as an anti-cancer drug entrapped in a new generation versatile carriers nanostructured lipid carrier (N...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1016/j.xphs.2025.103713 https://www.sciencedirect.com/science/article/pii/S0022354925001716 http://hdl.handle.net/10576/64059 |
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| _version_ | 1857415085237993472 |
|---|---|
| author | Iftikhar, Khan |
| author2 | Sabu, Maria Hussein, Nozad Omer, Huner Houacine, Chahinez Khan, Wasiq Elhissi, Abdelbary Yousaf, Sakib |
| author2_role | author author author author author author author |
| author_facet | Iftikhar, Khan Sabu, Maria Hussein, Nozad Omer, Huner Houacine, Chahinez Khan, Wasiq Elhissi, Abdelbary Yousaf, Sakib |
| author_role | author |
| dc.creator.none.fl_str_mv | Iftikhar, Khan Sabu, Maria Hussein, Nozad Omer, Huner Houacine, Chahinez Khan, Wasiq Elhissi, Abdelbary Yousaf, Sakib |
| dc.date.none.fl_str_mv | 2025-04-08T07:15:48Z 2025-02-27 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://dx.doi.org/10.1016/j.xphs.2025.103713 00223549 https://www.sciencedirect.com/science/article/pii/S0022354925001716 http://hdl.handle.net/10576/64059 1520-6017 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medical nebulizer Pulmonary system Drug delivery Liquid lipid Solid lipid Cancer |
| dc.title.none.fl_str_mv | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Aerosolization is a non-invasive approach of delivering drugs for both localized and systemic effects, specifically pulmonary targeting. The aim of this study was to deliver trans-resveratrol (TR) as an anti-cancer drug entrapped in a new generation versatile carriers nanostructured lipid carrier (NLC) to protect degradation and improve bioavailability via medical nebulizers. Twelve TR-NLC (i.e., F1-F12) formulations were prepared using different combinations and ratios of formulation ingredients via hot high-pressure homogenization. Upon analysis, formulations F1 and F2 demonstrated a particle size of <185 nm, a polydispersity index (PDI) <0.25, Zeta potential values of ∼30 mV and an entrapment efficiency >94%. The aerosolization performance of the F1 and F2 formulations was performed via a next generation impactor (NGI), using medical nebulizers. The air jet nebulizer demonstrated lower drug deposition in the earlier stages (1-2) and significantly higher deposition in the latter stages 3-5 (for both formulations), targeting middle to lower lung deposition. Moreover, the air jet nebulizer exhibited significantly higher emitted dose (ED) (87.44 ± 3.36%), fine particle dose (FPD) (1652.52 ± 9.68 µg) fine particle fraction (FPF) (36.25 ± 4.26%), and respirable fraction (RF) (93.41 ± 4.03%) when the F1 formulation was used as compared to the F2 formulation. Thus, the TR-NLC F1 formulation and air jet nebulizer were identified as the best combination for the delivery and targeting peripheral lungs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | qu_fdd3a0632a7c1c899fb34807d9d1e845 |
| identifier_str_mv | 00223549 1520-6017 |
| language_invalid_str_mv | en |
| network_acronym_str | qu |
| network_name_str | Qatar University repository |
| oai_identifier_str | oai:qspace.qu.edu.qa:10576/64059 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| spelling | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizersIftikhar, KhanSabu, MariaHussein, NozadOmer, HunerHouacine, ChahinezKhan, WasiqElhissi, AbdelbaryYousaf, SakibMedical nebulizerPulmonary systemDrug deliveryLiquid lipidSolid lipidCancerAerosolization is a non-invasive approach of delivering drugs for both localized and systemic effects, specifically pulmonary targeting. The aim of this study was to deliver trans-resveratrol (TR) as an anti-cancer drug entrapped in a new generation versatile carriers nanostructured lipid carrier (NLC) to protect degradation and improve bioavailability via medical nebulizers. Twelve TR-NLC (i.e., F1-F12) formulations were prepared using different combinations and ratios of formulation ingredients via hot high-pressure homogenization. Upon analysis, formulations F1 and F2 demonstrated a particle size of <185 nm, a polydispersity index (PDI) <0.25, Zeta potential values of ∼30 mV and an entrapment efficiency >94%. The aerosolization performance of the F1 and F2 formulations was performed via a next generation impactor (NGI), using medical nebulizers. The air jet nebulizer demonstrated lower drug deposition in the earlier stages (1-2) and significantly higher deposition in the latter stages 3-5 (for both formulations), targeting middle to lower lung deposition. Moreover, the air jet nebulizer exhibited significantly higher emitted dose (ED) (87.44 ± 3.36%), fine particle dose (FPD) (1652.52 ± 9.68 µg) fine particle fraction (FPF) (36.25 ± 4.26%), and respirable fraction (RF) (93.41 ± 4.03%) when the F1 formulation was used as compared to the F2 formulation. Thus, the TR-NLC F1 formulation and air jet nebulizer were identified as the best combination for the delivery and targeting peripheral lungs.Elsevier2025-04-08T07:15:48Z2025-02-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.xphs.2025.10371300223549https://www.sciencedirect.com/science/article/pii/S0022354925001716http://hdl.handle.net/10576/640591520-6017enhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:qspace.qu.edu.qa:10576/640592025-04-08T19:06:32Z |
| spellingShingle | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers Iftikhar, Khan Medical nebulizer Pulmonary system Drug delivery Liquid lipid Solid lipid Cancer |
| status_str | publishedVersion |
| title | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| title_full | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| title_fullStr | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| title_full_unstemmed | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| title_short | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| title_sort | Trans-resveratrol-loaded nanostructured lipid carrier formulations for pulmonary drug delivery using medical nebulizers |
| topic | Medical nebulizer Pulmonary system Drug delivery Liquid lipid Solid lipid Cancer |
| url | http://dx.doi.org/10.1016/j.xphs.2025.103713 https://www.sciencedirect.com/science/article/pii/S0022354925001716 http://hdl.handle.net/10576/64059 |