Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation
Oxidative stress (OS) has been shown to have a negative effect on the autonomic nervous system (ANS) and on ANS modulation of heart rate. Mitochondrial ATP production is the main source of reactive oxygen species (ROS) and hence the regulation of ROS becomes an important issue in maintaining optimal...
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2022
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| Online Access: | https://cinc.org/2022/Program/accepted/223_Preprint.pdf https://depot.sorbonne.ae/handle/20.500.12458/1349 |
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| _version_ | 1857415062281519104 |
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| author | Feng, Samuel |
| author2 | Yousef, Hibba Khandoker, Ahsan H. Tarvainen, Mika P. Jelinek, Herbert F. |
| author2_role | author author author author |
| author_facet | Feng, Samuel Yousef, Hibba Khandoker, Ahsan H. Tarvainen, Mika P. Jelinek, Herbert F. |
| author_role | author |
| dc.creator.none.fl_str_mv | Feng, Samuel Yousef, Hibba Khandoker, Ahsan H. Tarvainen, Mika P. Jelinek, Herbert F. |
| dc.date.none.fl_str_mv | 2022 2023-01-03T07:22:02Z 2023-01-03T07:22:02Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://cinc.org/2022/Program/accepted/223_Preprint.pdf https://depot.sorbonne.ae/handle/20.500.12458/1349 10.22489/CinC.2022.223 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Computing in Cardiology (CinC 2022) |
| dc.title.none.fl_str_mv | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| dc.type.none.fl_str_mv | Controlled Vocabulary for Resource Type Genres::text::conference object::conference proceedings |
| description | Oxidative stress (OS) has been shown to have a negative effect on the autonomic nervous system (ANS) and on ANS modulation of heart rate. Mitochondrial ATP production is the main source of reactive oxygen species (ROS) and hence the regulation of ROS becomes an important issue in maintaining optimal ANS functionality. Humanin (HN), a mitochondrial-derived peptide, plays an important role in lowering OS. Sympathovagal balance was assessed in 124 healthy participants through heart rate variability (HRV) analysis and compared across changes in HN concentrations divided into quintiles, with values of HN ranging from 64.6 to 343.2 pg/mL. Significant differences included various frequency domain and nonlinear HRV parameters, particularly between first and fourth HN quintiles with p values < 0.001 for recurrence plot analysis (RPA), detrended fluctuation analysis (DFA) a1 and Poincaré plot ratio SD1/SD2. The results revealed non-monotonic relationships between measures of HRV and HN concentration. A mitohormetic type of relationship was observed with HRV features increasing and then decreasing with increasing HN concentration. These results are consistent with previous findings of the importance of HN levels in regulating OS and extend these by revealing a concomitant effect on the modulation of cardiac rhythm by the ANS. |
| id | sorbonner_2bae8fc01a6fff8976b46d0e1033ccb2 |
| identifier_str_mv | 10.22489/CinC.2022.223 |
| language_invalid_str_mv | en |
| network_acronym_str | sorbonner |
| network_name_str | Sorbonne University Abu Dhabi repository |
| oai_identifier_str | oai:depot.sorbonne.ae:20.500.12458/1349 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic RegulationFeng, SamuelYousef, HibbaKhandoker, Ahsan H.Tarvainen, Mika P.Jelinek, Herbert F.Oxidative stress (OS) has been shown to have a negative effect on the autonomic nervous system (ANS) and on ANS modulation of heart rate. Mitochondrial ATP production is the main source of reactive oxygen species (ROS) and hence the regulation of ROS becomes an important issue in maintaining optimal ANS functionality. Humanin (HN), a mitochondrial-derived peptide, plays an important role in lowering OS. Sympathovagal balance was assessed in 124 healthy participants through heart rate variability (HRV) analysis and compared across changes in HN concentrations divided into quintiles, with values of HN ranging from 64.6 to 343.2 pg/mL. Significant differences included various frequency domain and nonlinear HRV parameters, particularly between first and fourth HN quintiles with p values < 0.001 for recurrence plot analysis (RPA), detrended fluctuation analysis (DFA) a1 and Poincaré plot ratio SD1/SD2. The results revealed non-monotonic relationships between measures of HRV and HN concentration. A mitohormetic type of relationship was observed with HRV features increasing and then decreasing with increasing HN concentration. These results are consistent with previous findings of the importance of HN levels in regulating OS and extend these by revealing a concomitant effect on the modulation of cardiac rhythm by the ANS.2023-01-03T07:22:02Z2023-01-03T07:22:02Z2022Controlled Vocabulary for Resource Type Genres::text::conference object::conference proceedingsapplication/pdfhttps://cinc.org/2022/Program/accepted/223_Preprint.pdfhttps://depot.sorbonne.ae/handle/20.500.12458/134910.22489/CinC.2022.223enComputing in Cardiology (CinC 2022)oai:depot.sorbonne.ae:20.500.12458/13492023-11-23T09:38:37Z |
| spellingShingle | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation Feng, Samuel |
| title | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| title_full | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| title_fullStr | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| title_full_unstemmed | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| title_short | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| title_sort | Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation |
| url | https://cinc.org/2022/Program/accepted/223_Preprint.pdf https://depot.sorbonne.ae/handle/20.500.12458/1349 |