Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension
Type II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent comorbidity of T2DM, with the co-occurrence of both conditions increasing the risk of diabetes-associated complications. Inflammation a...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2023
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://depot.sorbonne.ae/handle/20.500.12458/1445 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1857415063191683072 |
|---|---|
| author | Yousef, Hibba |
| author2 | Khandoker, Ahsan H. Feng, Samuel Helf, Charlotte Jelinek, Herbert F. |
| author2_role | author author author author |
| author_facet | Yousef, Hibba Khandoker, Ahsan H. Feng, Samuel Helf, Charlotte Jelinek, Herbert F. |
| author_role | author |
| dc.creator.none.fl_str_mv | Yousef, Hibba Khandoker, Ahsan H. Feng, Samuel Helf, Charlotte Jelinek, Herbert F. |
| dc.date.none.fl_str_mv | 2023-11-30T06:40:41Z 2023-11-30T06:40:41Z 2023 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 1664-2392 https://depot.sorbonne.ae/handle/20.500.12458/1445 10.3389/fendo.2023.1173402 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Frontiers in Endocrinology |
| dc.subject.none.fl_str_mv | type II diabetes hypertension oxidative stress inflammation mitochondrial dysfunction prediabetes |
| dc.title.none.fl_str_mv | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| dc.type.none.fl_str_mv | Controlled Vocabulary for Resource Type Genres::text::periodical::journal::contribution to journal::journal article |
| description | Type II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent comorbidity of T2DM, with the co-occurrence of both conditions increasing the risk of diabetes-associated complications. Inflammation and oxidative stress (OS) have been identified as leading factors in the development and progression of both T2DM and HT. However, OS and inflammation processes associated with these two comorbidities are not fully understood. This study aimed to explore changes in the levels of plasma and urinary inflammatory and OS biomarkers, along with mitochondrial OS biomarkers connected to mitochondrial dysfunction (MitD). These markers may provide a more comprehensive perspective associated with disease progression from no diabetes, and prediabetes, to T2DM coexisting with HT in a cohort of patients attending a diabetes health clinic in Australia. |
| id | sorbonner_77b319839823593dbc422b30d977cd8b |
| identifier_str_mv | 1664-2392 10.3389/fendo.2023.1173402 |
| language_invalid_str_mv | en |
| network_acronym_str | sorbonner |
| network_name_str | Sorbonne University Abu Dhabi repository |
| oai_identifier_str | oai:depot.sorbonne.ae:20.500.12458/1445 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertensionYousef, HibbaKhandoker, Ahsan H.Feng, SamuelHelf, CharlotteJelinek, Herbert F.type II diabeteshypertensionoxidative stressinflammationmitochondrial dysfunctionprediabetesType II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent comorbidity of T2DM, with the co-occurrence of both conditions increasing the risk of diabetes-associated complications. Inflammation and oxidative stress (OS) have been identified as leading factors in the development and progression of both T2DM and HT. However, OS and inflammation processes associated with these two comorbidities are not fully understood. This study aimed to explore changes in the levels of plasma and urinary inflammatory and OS biomarkers, along with mitochondrial OS biomarkers connected to mitochondrial dysfunction (MitD). These markers may provide a more comprehensive perspective associated with disease progression from no diabetes, and prediabetes, to T2DM coexisting with HT in a cohort of patients attending a diabetes health clinic in Australia.2023-11-30T06:40:41Z2023-11-30T06:40:41Z2023Controlled Vocabulary for Resource Type Genres::text::periodical::journal::contribution to journal::journal articleapplication/pdf1664-2392https://depot.sorbonne.ae/handle/20.500.12458/144510.3389/fendo.2023.1173402enFrontiers in Endocrinologyoai:depot.sorbonne.ae:20.500.12458/14452023-11-30T18:00:24Z |
| spellingShingle | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension Yousef, Hibba type II diabetes hypertension oxidative stress inflammation mitochondrial dysfunction prediabetes |
| title | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| title_full | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| title_fullStr | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| title_full_unstemmed | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| title_short | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| title_sort | Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension |
| topic | type II diabetes hypertension oxidative stress inflammation mitochondrial dysfunction prediabetes |
| url | https://depot.sorbonne.ae/handle/20.500.12458/1445 |