Flexible Organic Crystals for Light Delivery in Biological Tissues
Optically transmissive materials are indispensable for the transmission of light or light-encoded signals in telecommunications and optobiomedical techniques. Here, we propose that slender crystals of small organic molecules can be used as optically transparent, flexible, lightweight, and emissive m...
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2024
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| Online Access: | https://depot.sorbonne.ae/handle/20.500.12458/1633 |
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| _version_ | 1857415063131914240 |
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| author | Lan, Linfeng |
| author2 | Pan, Xiuhong Commins, Patrick Li, Liang Catalano, Luca Yan, Dongmei Xiong, Haonan Wang, Chenguang Naumov, Panče Zhang, Hongyu |
| author2_role | author author author author author author author author author |
| author_facet | Lan, Linfeng Pan, Xiuhong Commins, Patrick Li, Liang Catalano, Luca Yan, Dongmei Xiong, Haonan Wang, Chenguang Naumov, Panče Zhang, Hongyu |
| author_role | author |
| dc.creator.none.fl_str_mv | Lan, Linfeng Pan, Xiuhong Commins, Patrick Li, Liang Catalano, Luca Yan, Dongmei Xiong, Haonan Wang, Chenguang Naumov, Panče Zhang, Hongyu |
| dc.date.none.fl_str_mv | 2024-06-25T09:05:45Z 2024-06-25T09:05:45Z 2024 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 2096-5745 https://depot.sorbonne.ae/handle/20.500.12458/1633 10.31635/ccschem.024.202404188 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | CCS Chemistry |
| dc.title.none.fl_str_mv | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| dc.type.none.fl_str_mv | Controlled Vocabulary for Resource Type Genres::text::periodical::journal::contribution to journal::journal article |
| description | Optically transmissive materials are indispensable for the transmission of light or light-encoded signals in telecommunications and optobiomedical techniques. Here, we propose that slender crystals of small organic molecules can be used as optically transparent, flexible, lightweight, and emissive media to deliver photons into or through biological tissues as an alternative to silica- or polymer-based light waveguides. We demonstrate that organic crystals remain transmissive in various porcine tissues, and their efficiency in light transduction depends on the intrinsic optical properties of the crystal, optical path, geometry of excitation, and the type of tissue. Moreover, elastically or plastically deformable organic crystals remain mechanically compliant and can be bent after they have been embedded in the tissue, opening prospects for designing a new class of biocompatible light waveguiding elements based on crystalline organic materials. In vivo implantation and toxicity assays capitalize on mechanical flexibility and biocompatibility in animal models. Within a broader context, the high transparency, anisotropy, and biocompatibility of some organic crystals turn this emerging class of materials into a prospective platform for delivering photons for specific interaction with target cells in tissues for applications such as photodynamic therapy and optogenetics. |
| id | sorbonner_81729e1893c3b879b3ccfd2fa820f146 |
| identifier_str_mv | 2096-5745 10.31635/ccschem.024.202404188 |
| language_invalid_str_mv | en |
| network_acronym_str | sorbonner |
| network_name_str | Sorbonne University Abu Dhabi repository |
| oai_identifier_str | oai:depot.sorbonne.ae:20.500.12458/1633 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Flexible Organic Crystals for Light Delivery in Biological TissuesLan, LinfengPan, XiuhongCommins, PatrickLi, LiangCatalano, LucaYan, DongmeiXiong, HaonanWang, ChenguangNaumov, PančeZhang, HongyuOptically transmissive materials are indispensable for the transmission of light or light-encoded signals in telecommunications and optobiomedical techniques. Here, we propose that slender crystals of small organic molecules can be used as optically transparent, flexible, lightweight, and emissive media to deliver photons into or through biological tissues as an alternative to silica- or polymer-based light waveguides. We demonstrate that organic crystals remain transmissive in various porcine tissues, and their efficiency in light transduction depends on the intrinsic optical properties of the crystal, optical path, geometry of excitation, and the type of tissue. Moreover, elastically or plastically deformable organic crystals remain mechanically compliant and can be bent after they have been embedded in the tissue, opening prospects for designing a new class of biocompatible light waveguiding elements based on crystalline organic materials. In vivo implantation and toxicity assays capitalize on mechanical flexibility and biocompatibility in animal models. Within a broader context, the high transparency, anisotropy, and biocompatibility of some organic crystals turn this emerging class of materials into a prospective platform for delivering photons for specific interaction with target cells in tissues for applications such as photodynamic therapy and optogenetics.2024-06-25T09:05:45Z2024-06-25T09:05:45Z2024Controlled Vocabulary for Resource Type Genres::text::periodical::journal::contribution to journal::journal articleapplication/pdf2096-5745https://depot.sorbonne.ae/handle/20.500.12458/163310.31635/ccschem.024.202404188enCCS Chemistryoai:depot.sorbonne.ae:20.500.12458/16332024-06-25T18:00:29Z |
| spellingShingle | Flexible Organic Crystals for Light Delivery in Biological Tissues Lan, Linfeng |
| title | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| title_full | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| title_fullStr | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| title_full_unstemmed | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| title_short | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| title_sort | Flexible Organic Crystals for Light Delivery in Biological Tissues |
| url | https://depot.sorbonne.ae/handle/20.500.12458/1633 |