Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. حسب P, Sneha

"…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …"
احصل على النص الكامل
احصل على النص الكامل

Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes حسب Younes, Noura B.

"…Methods: The objective of this study was to test the effects of DHA on the hypoxia responses (1.0 % for 24 hours) of 3T3-L1 adipocytes with a focus on oxidative stress, inflammation, and mitochondrial function, and antioxidant status. …"
احصل على النص الكامل

Docosahexaenoic Acid Counteracts the Hypoxic-Induced Inflammatory and Metabolic Alterations in 3T3-L1 Adipocytes حسب Younes, Noura B.

"…Metabolic parameters such as lactate, FFA, glycerol release, glucose uptake, and ATP content were assessed by a fluorometer. The expression of HIF-1, GLUT1 and the secretion of adipocytokines such as leptin, adiponectin, and pro-inflammatory markers was evaluated. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation حسب Feng, Samuel

"…A mitohormetic type of relationship was observed with HRV features increasing and then decreasing with increasing HN concentration. …"
احصل على النص الكامل
احصل على النص الكامل

Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin حسب Munusamy, Shankar

"…Compared with controls, ob/ob and LoxTB MC4R−/− mice exhibit significant albuminuria, increased creatinine clearance, and high renal triglyceride content. Renal ATP levels were decreased in both obesity models, and mitochondria isolated from both models showed alterations that would lower mitochondrial ATP production. …"
احصل على النص الكامل
احصل على النص الكامل

AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro حسب Allouch, Soumaya

"…Notably, metformin also prevented albumin-induced EMT; this was marked by a 50% decrease in a-SMA and a 60% increase in E-cadherin expression. …"
احصل على النص الكامل
احصل على النص الكامل

The Effects of Class IV Hemorrhagic Hypotensive Shock and Its Resuscitation with Fluids and Adjuvant Vasopressors or Cellular Energy Replenishment on the Splanchnic Microcirculatio... حسب Zakaria, El Rasheid

"…Class IV hemorrhagic shock caused differential arteriole responses with vasoconstriction from baseline of A1 and A2 ( − 22.1 ± 1.9%), and vasodilation of the A3 and A4 arterioles (+22.2 ± 2.8%). …"
احصل على النص الكامل
احصل على النص الكامل