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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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2
Understanding the Mechanism of Diabetes Mellitus in LRBA-Deficient Patient
منشور في 2023"…</p><h3>Hypothesis</h3><p dir="ltr">1) LRBA deficiency in the patient leads to decreased surface CTLA-4 expression level and therefore immune mediated type 1 diabetes mellitus. 2) LRBA protein may be involved in the insulin biosynthesis and secretion in β-cells.…"
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3
Ultra-low thermal conductivity in scheelite and A-deficient scheelite ceramics
منشور في 2021"…Structural, microstructural and thermal properties of both sintered ceramics were assessed to identify the impact of cation deficiency on thermal conductivity. BaMoO ceramic has shown a decrease in thermal conductivity from 0.8 W m K to 0.65 W m K from 400 K to 650 K. …"
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4
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…Proteomics analysis of skeletal muscle revealed a shift to increased heat shock proteins and mechanoprotection and repair in HSA-mUCP1 mice. Decreased MG-derived AGE protein content in skeletal muscle of aged HSA-mUCP1 mice is therefore likely produced by increased proteolysis of MG-modified proteins and increased proteostasis surveillance of the skeletal muscle proteome. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…Proteomics analysis of skeletal muscle revealed a shift to increased heat shock proteins and mechanoprotection and repair in HSA-mUCP1 mice. Decreased MG-derived AGE protein content in skeletal muscle of aged HSA-mUCP1 mice is therefore likely produced by increased proteolysis of MG-modified proteins and increased proteostasis surveillance of the skeletal muscle proteome. …"
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6
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …"
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7
apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes
منشور في 2021"…</p><h3>Conclusions</h3><p dir="ltr">Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …"
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8
Influence of temperature on tire-pavement noise in hot climates: Qatar case
منشور في 2021"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"
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Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study
منشور في 2025"…The aim of this study is to retrospectively evaluate outpatients with iron deficiency anemia who refused blood transfusion and were treated with intravenous iron supplementation. …"
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Clinical and Biochemical Analysis of Glutamate-Cysteine Ligase Deficiency Presented with Late-Onset Spinocerebellar Ataxia and Hemolytic Anemia
منشور في 2024"…Glutathione modulates multitudes of critical cellular processes and scavenges free radicals. Its deficiency is reported to cause hemolysis of variable severity and is a rare cause of neurological abnormalities such as spinocerebellar ataxia. …"
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11
The Effect of Number of Corrugation on Crashworthiness of Aluminum Corrugated Tube under Lateral Loading
منشور في 2017"…The results show that tubes with corrugations have a higher mean crushing force which is directly proportional to the number of corrugations. …"
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The investigation of treatment design parameters on carbon integration networks
منشور في 2023"…For this, an enhanced treatment model that captures all necessary treatment design parameters has been utilized alongside the original model. …"
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13
Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
منشور في 2025"…Furthermore, semaglutide was the only effective Glucagon Like Peptide-1 Receptor Agonist in reducing Low-Density Lipoprotein and total cholesterol levels, with mean differences of -0.16 mmol/L and -0.48 mmol/L, respectively. …"
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14
Influence of temperature on tire-pavement noise in hot climates: Qatar case
منشور في 2021"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"
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15
The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in <i>Drosophila melanogaster</i>
منشور في 2023"…<p dir="ltr">1p32.3 microdeletion/duplication is implicated in many neurodevelopmental disorders-like phenotypes such as developmental delay, intellectual disability, autism, macro/microcephaly, and dysmorphic features. …"
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Optimization of design and operation of solar assisted district cooling systems
منشور في 2020"…This research aims at making this technology more affordable by providing a holistic optimization design of solar assisted district cooling systems. …"
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17
Comprehensive thermoeconomic, exergoeconomic, and optimization analyses of direct oxy‐combustion supercritical CO<sub>2</sub> intercooled and reheated cycles under design and off‐d...
منشور في 2022"…At optimized conditions (<i>P</i><sub>c,o</sub> = 30 MPa, Pc,o = 8 MPa, TIT = 744°C, CIT = 30°C [wet‐cooling]), the ICC shows superior energetic performance (52.08%) compared to 47.97% for DRC, 49.20% for PIC, and 48.62% for RHC. At off‐design conditions with a power demand (PD) of 40% of the design load (50 MW), the thermal efficiency is decreased by 21.82% in DRC, 17.71% in ICC, 22.46% in PIC, and 13.60% in RHC. …"
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18
Novel Ternary Adder and Multiplier Designs Without Using Decoders or Encoders
منشور في 2021"…Extensive simulations (over 160) of the proposed designs in terms of PVT (Process, Voltage, Temperature) variations, noise effect, and scalability studies, along with several benchmark designs using HSPICE simulator, prove the significance of the proposed circuits to decrease the power-delay product (PDP), improve the robustness to process variations, and the noise tolerance. …"
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Ultra-Low Energy CNFET-Based Ternary Combinational Circuits Designs
منشور في 2021"…The target of this work is to decrease energy consumption by (1) using Multiple-valued logic (MVL) that shows notable enhancements regarding energy consumption over binary circuits and (2) using carbon nanotube field-effect transistors (CNFET) that show better performance than CMOS. …"
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20
Designing a Carbon Utilization Network: From Stationary Sources to Agricultural Greenhouses
منشور في 2025"…By fostering innovation and strategic alignment, we can secure a sustainable, productive, and resilient global food system, particularly in arid regions like Qatar, which are facing significant agricultural challenges.…"