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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Quality Issues In Online Distance Learning
منشور في 2020"…The objective of this research is to determine the quality issues of online distance learning and explore the factors which affect the quality of online education. …"
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Trade Flow and Nation Brand Distance: A Structural Gravity Model Approach
منشور في 2021"…The results on the impact of NBD on FTA and trade flows provides some interesting insights as the there is a negative and significant moderation impact of NBD on the relationship between FTA and both export and import volume which suggest that a decrease of NBD will increase the effect of FTA on trade flow. …"
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Can Ease of Doing Business Shorten the Distance and Attract Foreign Direct Investment
منشور في 2021"…The empirical result also revealed that there is a significant moderating effect of doing business on the relationship between institutional distance and FDI inflows. …"
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Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution
منشور في 2022"…Multicasting a video session for distance learning significantly lowers the burden on core and Radio Access Networks (RAN) as demonstrated by evaluation over a real-world dataset. …"
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Investigating Science Distance Learning Strategies in COVID-19 and their Impact on SOD students in American Curriculum Schools in the UAE
منشور في 2021"…Recently, the need to use technology appears more due to the current global crisis of coronavirus pandemic as a significant educational tool. The main purpose of this study is to examine the effect of using distance learning in the science subject on SOD students’ outcomes from the teachers’, students’, and parents’ perceptions on different cases of SOD students in some American curriculum schools in the UAE. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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The Impact of Distance Learning On Students of Determination’s Educational and Social-Emotional Skills in Dubai Private Schools from The Parents’ and Teachers’ Perspectives
منشور في 2022"…The study begins by explaining the rationale for exploring the opportunities and challenges created by distance learning. Consequently, the literature review section elaborates the findings of recent qualitative and quantitative research articles about distance education and its effects on conventional learning paradigms. …"
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