Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Among the affected signaling networks were TGFβ1, SPP1, and ERK regulatory networks. Conclusions. We identified γ-secretase inhibitor (LY411575) as a potent regulator of osteoblastic differentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with ectopic bone formation.…"

COVID-19 and Anemia: What Do We Know So Far? حسب Luai Abu-Ismail (10712857)

LDL-C Targets in Secondary Prevention: How Low Should We Go? حسب Karim Bayoumy (3496688)

"…<h3>Abstract</h3><p dir="ltr">The benefits of lowering low-density lipoprotein cholesterol (LDL-C), mainly using high-intensity statin therapy, and its impact on decreasing the recurrence of atherosclerotic cardiovascular disease (ASCVD) in secondary prevention has been well established. …"

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy حسب Hamed Elgendy (14148846)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit Masania (7164239)

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"

The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis حسب Hoda Gad (6470522)

"…Quality assessment was done using the ROBINS-I and Cochrane tools for risk of bias and analyses were performed using RevMan version 5.1.…"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"

Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex حسب Wesam S. Ahmed (10170053)

"…<p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences <a href="https://dx.doi.org/10.3389/fmolb.2022.846996" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.846996</a>, published online 22 July 2022.…"

Correlating the rheological and magneto-optical properties of cobalt substituted magnetite ferrofluids (Co_xFe_1−xFe₂O₄) with theoretical... حسب Blessy Babukutty (17871482)

"…An environmental friendly method of co-precipitation is applied to generate Co_xFe_1−xFe₂O₄ with variable dopant concentration (x = 0–0.8), which is deeply investigated by structural and functional property analyses of the ferrofluids. …"

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications حسب Sumama Nuthana Kalva (17302906)

"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

Accelerating Care: Enhancing Patient Satisfaction through a Quality Initiative in the Obstetrics and Gynaecology Emergency Department at Al Wakra Hospital, Qatar حسب Lolwa Al Ansari (18466227)

"…The proportion of patients spending less than 8 hours in the OB ED observation beds rose from 74% in January 2022 to over 98% in 2023. Notably, there was a remarkable decrease in patients who Left Without Being Seen (LWBS) and in absconded patient rates from 2020 to 2023 (Figure 2).…"

Removal of Benzene and Toluene from Synthetic Wastewater by Adsorption onto Magnetic Zeolitic Imidazole Framework Nanocomposites حسب George Z. Kyzas (740387)

"…Thus, by performing the present study, the potential of Fe₃O₄/zeolite imidazolate framework nanoparticles (Fe₃O₄@ZIF-8) was evaluated for the adsorption of benzene and toluene. …"

Geomorphological changes in the coastal area of Farasan Al-Kabir Island (Saudi Arabia) since mid Holocene based on a multi-proxy approach حسب Pavlopoulos, Kosmas

"…The geomorphological evolution of the southeastern coastal area of Farasan Al-Kabir Island (Saudi Arabia) is revealed by the mapping of modern landforms and a multi-proxy and high spatial resolution study including grain size, particulate organic carbon, mineralogy, element geochemistry, benthic foraminifera analysis and radiocarbon dating of a 3.3-m long sediment core. …"
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Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings حسب Khan, M.S.

"…This research aims to develop an innovative solution by incorporating AlN nanoparticles with various concentrations (0.1, 0.2, 0.4, and 0.8 g/L) as reinforcement in the Ni-P electrolyte to develop composite coatings using A36 carbon steel as a substrate through direct current (DC) electrodeposition method. …"
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Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings حسب M.S. Khan (22047413)

"…This research aims to develop an innovative solution by incorporating AlN nanoparticles with various concentrations (0.1, 0.2, 0.4, and 0.8 g/L) as reinforcement in the Ni-P electrolyte to develop composite coatings using A36 carbon steel as a substrate through direct current (DC) electrodeposition method. …"

Drying Studies of Purple Non-Sulphur Bacterial Biomass and Application as a Single-Cell Protein Feed for <i>Litopenaeus vannamei</i> حسب Asifa Anwar (20884229)