A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"

Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex حسب Wesam S. Ahmed (10170053)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit Masania (7164239)

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …"

Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country حسب Mohamad Y. Khatib (11659459)

"…<h3>Background and Aims</h3><p dir="ltr">Clinical characteristics and factors associated with mortality in patients admitted to the intensive care unit (ICU) in countries with low case fatality rates (CFR) are unknown. We sought to determine these in a large cohort of critically ill COVID-19 patients in Qatar and explore the early mortality predictors. …"

The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review حسب Mahmoud Yousef (9900837)

"…The majority of the investigated biotics exhibited positive effects on COVID-19 patients, manifesting in symptom alleviation, inflammation reduction, and notable decreases in mortality rates. …"

Case report: Safety and efficacy of voxelotor in a patient with sickle cell disease and stage IV chronic kidney disease حسب Awni Alshurafa (15468195)

"…Herein we report a 49-year-old man, with sickle cell disease and stage IV chronic kidney disease, who was managed successfully with voxelotor and resulted in decreasing transfusion requirement and vaso-occlusive painful crisis without affecting kidney function.…"

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... حسب Salma, Younes

"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

"…<div><p>Selenium application as sodium selenate was repeatedly shown to have anti-carcinogenic properties by increasing levels of the serine/ threonine protein phosphatase 2A (PP2A) in cancer cells. PP2A has a prominent role in cell development, homeostasis, and in neurons regulates excitability. …"

Forecast of the outbreak of COVID-19 using artificial neural network: Case study Qatar, Spain, and Italy حسب Moayyad Shawaqfah (17280637)

"…The model sensitivity was analyzed using the root mean square error (RMSE), the mean absolute percentage error and the regression coefficient index R2, which yielded highly accurate values of the predicted correlation for the infected and dead cases of 0.99 for the dates considered. The verified and validated growth model of COVID-19 for these countries showed the effects of the measures taken by the government and medical sectors to alleviate the pandemic effect and the effort to decrease the spread of the virus in order to reduce the death rate. …"

Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome حسب Hammad Shabir Chaudhry (20376378)

"…We present a rare case of a 46-years-old female with systemic amyloidosis secondary to AL amyloidosis manifesting primarily as nephrotic syndrome and AIH-PSC overlap syndrome.…"

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome حسب Abu Saleh Md Moin (6189512)

"…</p><p dir="ltr">Correction: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome: <a href="https://doi.org/10.1186/s12967-021-02782-w" rel="noreferrer" target="_blank">https://doi.org/10.1186/s12967-021-02782-w</a>, published online 15 March 2021.…"

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... حسب Salma Younes (6424865)

"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). …"

From COVID-19 to clot: the involvement of the complement system حسب Mohamed A. Hendaus (9401919)

"…This role can stipulate a groundwork for further investigation of the pathophysiologic importance of complement in COVID-19, and could propose targets for specific intervention. …"

Effects of COVID-19 on Autism Spectrum Disorder in Qatar حسب Fouad A. Alshaban (17281108)

"…</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Psychiatry<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fpsyt.2024.1322011" target="_blank">https://dx.doi.org/10.3389/fpsyt.2024.1322011</a></p>…"

The diagnostic dilemma of bilateral optic neuritis and idiopathic intracranial hypertension coexistence in a patient with recent COVID‐19 infection حسب Sundus Sardar (14571097)

"…<p></p><div> <p>Owing to autoantibody production and thrombophilic disorders in COVID-19, physicians must have low threshold to investigate secondary IIH and demyelinating disorders in patients with headache and decreased vision following recent COVID-19 infection.…"

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells حسب Ali Alhoshani (3720718)

"…</p><h3>Results</h3><p dir="ltr">Treatment of human breast cancer cells with increasing concentrations of VCX caused a significant decrease in cells growth and proliferation. …"

A dramatized method for teaching undergraduate students responsible research conduct حسب Kuei-Chiu Chen (14108854)

Fanconi–Bickel Syndrome: A Review of the Mechanisms That Lead to Dysglycaemia حسب Sanaa Sharari (12561952)

"…Missense, nonsense, frame-shift (fs), in-frame indels, splice site, and compound heterozygous variants have all been identified in SLC2A2 gene of FBS cases. Approximately 144 FBS cases with 70 different SLC2A2 gene variants have been reported so far. …"