Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
احصل على النص الكامل
احصل على النص الكامل

Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening. حسب Shurbaji, Samar

احصل على النص الكامل
احصل على النص الكامل

Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. حسب Seidel, Monika

"…The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. …"
احصل على النص الكامل
احصل على النص الكامل

Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar حسب Abdelrahman, Doua

"…Results: Only 1.4% (70/5026) of the samples had detectible B19V DNA in their blood. B19V DNA prevalence statistically decreased with age (p = 0.03). …"
احصل على النص الكامل
احصل على النص الكامل

Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK حسب Patel, Shivalee

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Hyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis حسب Athanasiadou, Ioanna

"…Baseline urinary LH concentrations, expressed as the mean � SD for each individual, were within the acceptable physiological range (7.11 � 5.42 IU/L). A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 � 5.60 IU/L and Phase B: 4.74 � 4.72 IU/L) with the baseline (''normal'') values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. …"
احصل على النص الكامل
احصل على النص الكامل

Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits حسب Garavelo, Sherrira M.

احصل على النص الكامل
احصل على النص الكامل

Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats حسب Kiss, K.

"…In study 4, AF43136 at 10 mg/kg decreased infarct size, similarly to the positive control CsA compared to the appropriate vehicle (39.4 ± 5.9% vs. 58.1 ± 5.4% and 45.9 ± 2.4% vs. 63.8 ± 4.1%, p < 0.05, respectively). …"
احصل على النص الكامل
احصل على النص الكامل

Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis حسب Zakaria, Zain Zaki

"…The reduction of the expression of PRMT5 also resulted in a 4-fold decrease in the rate of hatching and had negative impacts on locomotion and tail flicking in PRMT5 morphants. …"
احصل على النص الكامل

Decreased weight gain and enhanced serum biochemical parameters in rats after vitamin D and Ca supplementation حسب Subih H.

احصل على النص الكامل
احصل على النص الكامل

Complex-impedance response of an Ag/TeO2-V2O5/Ag structure حسب El-Muraikhi, M.

"…The ac conductivity of glass samples of composition 50 mol% TeO2 and 50 mol% V2O5 has been analyzed. The samples were prepared by the usual melt-quench method. …"
احصل على النص الكامل
احصل على النص الكامل

A comparative study of the growth of Tetraselmis sp. in large scale fixed depth and decreasing depth raceway ponds حسب Das, Probir

احصل على النص الكامل
احصل على النص الكامل

Evidence of two mechanisms involved in Bacillus thuringiensis israelensis decreased toxicity against mosquito larvae: Genome dynamic and toxins stability حسب Elleuch, Jihen

"…The obtained results describe two main reasons of the decrease of B. thuringiensis israelensis insecticidal activity. …"
احصل على النص الكامل
احصل على النص الكامل

Repositioning of the global epicentre of non-optimal cholesterol حسب Taddei, Cristina

"…These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effects of superelastic nano-NiTi additions on electroless Ni –P coating properties under bending حسب MacLean M.

"…In this study, electroless Ni –P-nano-NiTi composite coatings containing 5.14 wt%, 6.07 wt%, and 7.02 wt % NiTi were subjected to three-point bend testing in order to determine bending properties. …"
احصل على النص الكامل
احصل على النص الكامل

Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar حسب Chemaitelly, Hiam

"…In the pre-omicron phase, first omicron wave, and combined phases, it was 2.01 (95% CI 1.90 to 2.13), 3.70 (95% CI 3.25 to 4.22) and 2.18 (95% CI 2.07 to 2.30) per 1000 person years, respectively. …"
احصل على النص الكامل
احصل على النص الكامل

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections حسب Qassim, Suelen H.

"…In 2021, Qatar experienced considerable incidence of SARS-CoV-2 infection that was dominated sequentially by the Alpha, Beta, and Delta variants. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats . حسب Djouhri, Laiche

"…Consistent with this hypothesis, we found (7 days post-SNA), in SNA rats with established pain hypersensitivity, slower AP kinetics in axotomized L5-neurons and faster AP kinetics in L4-nociceptive neurons including decreased rise time in Aδ-and Aβ-fiber nociceptors, and after-hyperpolarization duration in Aβ-fiber nociceptors. …"
احصل على النص الكامل
احصل على النص الكامل