Association between Insulin and Nitric Oxide in Human Retinal Microvascular Endothelial Cells in vitro حسب Rizk, Nasser Moustafa

"…Insulin treatment caused an up regulation of IRS-1 and IRS-2 genes after 1 hour however, PI3K, Akt and eNOS were significantly reduced. The analysis of angiogenic and proapoptotic markers VEGFA and NFkB by RT-PCR showed no significant change in the expression of NFkB in hyperglycemic alone, hyperglycemic and normoglycemic cells with insulin treatment at all-time points. …"
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