A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. …"

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. …"

Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex حسب Wesam S. Ahmed (10170053)

"…This sentence previously stated:</p><p dir="ltr">“Representative trajectory movies of the 10 ns simulations were prepared from 5,000 trajectory snapshots (50 snapshots/ns) generated using VMD Movie Maker Tool (Humphrey et al., 1996) and compiled using Fiji distribution of ImageJ software (Schindelin et al., 2012) at a frame rate of 300 fps.”…"

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... حسب Salma, Younes

"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... حسب Salma Younes (6424865)

"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …"

An additive manufacturing approach based on electrohydrodynamic printing to fabricate P3HT:PCBM thin films حسب Zulfikre Esa (19457344)

"…We report here on the fabrication of poly(3-hexylthiophene): phenyl-C61-butyric acid methyl ester (P3HT:PCBM) thin films through the electrohydrodynamic atomization (EHDA) process and its integration as absorber layer for organic solar cells. …"

Deep Reinforcement Learning Powered IRS-Assisted Downlink NOMA حسب Muhammad Shehab (16904880)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit Masania (7164239)

"…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…"

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…Decreased formation and increased clearance of MG-derived AGEs may be associated with healthy aging in the HSA-mUCP1 mouse.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes حسب Manjunath Ramanjaneya (14603468)

"…The fact that apoA2 correlated with gestational age at delivery in both control women and women with GDM raises the hypothesis that apoA2 may be used as a biomarker of premature delivery, and this warrants further investigation.…"

Effect of speed and gradient on plantar force when running on an AlterG® treadmill حسب Athol Thomson (6651008)

"…<h3>Background</h3><p dir="ltr">Anti-gravity treadmills are used to decrease musculoskeletal loading during treadmill running often in return to play rehabilitation programs. …"

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs حسب Salam Salloum-Asfar (656363)

"…Decreased levels of let-7a-5p showed an increase of SP8 as described previously. …"

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications حسب Jingxuan Shan (4711089)

"…<i>CCL5</i> variants (<b>rs2107538</b> and <b>rs2280789</b>) were linked to CCL5 serum and mRNA levels. …"

Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis حسب George Nitzburg (18614989)

"…<h3>Background</h3><p dir="ltr">Brief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. …"

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers حسب Madisa V.G., Varaprasad

"…The entire globe is now focused on generating power using solar photovoltaic (SPV) cells. The SPV is generating the DC power, by using power converters to satisfy the load requirement. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs حسب Raed Shalaby (3756112)

"…Our results revealed that these selected chalcone analogs increased dopamine levels in the rat hepatoma (H4IIE) cells and decreased the relative mRNA expression of the MAO-B enzyme.…"