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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
منشور في 2021"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …"
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…"
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Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
منشور في 2025"…Furthermore, semaglutide was the only effective Glucagon Like Peptide-1 Receptor Agonist in reducing Low-Density Lipoprotein and total cholesterol levels, with mean differences of -0.16 mmol/L and -0.48 mmol/L, respectively. …"
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Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic
منشور في 2023"…Higher stability of the ferroelectric (FE) phase was obtained at room temperature for the compositions y = 0.01, 0.02 and 0.05, with optimum values for y = 0.02 as remanent polarization Pr = 32µC/cm2, as well as piezoelectric coefficients d33 = 137 pC/N, kp = 0.27 and kt = 0.16, whereas a higher content of Dy (y = 0.08) induced a remarkable decrease of the ferroelectric and piezoelectric properties. …"
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Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study
منشور في 2024"…Increasing condom use from 10 % to 50 % lowers NG prevalence among FSWs, clients, and their spouses from 12.2 % to 6.4 %, 1.2 % to 0.5 %, and 0.4 % to 0.2 %, respectively. …"
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
منشور في 2024"…However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. …"
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Control of the Speed of a Light-Induced Spin Transition through Mesoscale Core-Shell Architecture
منشور في 2018"…A series of photomagnetic coordination polymer core-shell heterostructures, based on the light-switchable RbaCob[Fe(CN)6]c·mH2O (RbCoFe-PBA) as core with the isostructural KjNik[Cr(CN)6]l·nH2O (KNiCr-PBA) as shell, are studied using temperature-dependent powder X-ray diffraction and SQUID magnetometry. …"
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Epibenthic communities from offshore platforms in the Arabian Gulf are structured by platform age and depth
منشور في 2021"…A step further is now required to determine whether these platform foundations should be converted to reefs after their decommissioning (i.e., Rigs to Reefs approach).…"
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Influence of shelf-life duration on mechanical, thermal and shape recovery motion derivatives of shape memory polyurethane
منشور في 2024"…The results indicated that tensile and flexural strength decreased by 35.16 % and 29.3 % respectively, from S1 to S10. …"
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Extraction and characterization of biofunctional lignocellulosic fibers from Pulicaria undulata plant and the effect of alkali treatment on their bio-physicochemical properties
منشور في 2024"…The average yield of raw fibers obtained was 28.1 %. The raw fibers of P. undulata were rich in cellulose (36.2 %), followed by hemicellulose (30.3 %), lignin (16.2 %), moisture (11.1 %), and pectin (3.9 %). …"
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Empirical evaluation of change in crash risk due to lane marking reallocation: A case study in Kochi City, Japan
منشور في 2023"…In addition, the results indicate that the PICUD value tends to decrease (i.e., the crash risk tends to increase) with increasing speed of the following vehicle relative to the leading vehicle. …"
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes
منشور في 2025"…The financial value of PALYs was determined based on the gross domestic product (GDP) per full-time worker (i.e. US$80,573). The base-case model estimated the productivity burden of CVD, and interventional scenarios were simulated to assess potential gains resulting from improved control of modifiable risk factors, including reduced incidence of T2D, lower systolic blood pressure (SBP), decreased number of smokers, and reduced total cholesterol. …"
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