Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming حسب Mohamed, Assem T.

"…On the other hand, at the same time-on-stream LaNiMgO-Rh lost 0.3 and 0.7 % of its maximum CO2 and CH4 conversions, respectively.In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO2 conversion from 77.6 % to 70.5%, the CH4 conversion decreased from 72.3% to 64.2%. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim, Al-Fahdawi

"…Pt/MgO nanoparticles downregulated Bcl-2 and upregulated Bax and p53 tumor suppressor proteins in the cancer cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S., El-Shoukrofy

"…The two most effective 15-LOX inhibitors, 2a and 2b, exhibited 69 % and 57 % of quercetin's action, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants حسب Bin, Zhou

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Coalition game theoretic P2P trading in a distribution network integrity-ensured local energy market حسب M., Imran Azim

"…This paper presents a peer-to-peer (P2P) trading-enabled local energy market (LEM) mechanism and analyses it in the Australian market context to verify its feasibility. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes حسب Abushanab, Dina

"…However, implementing interventions to decrease the T2D incidence, lower SBP, reduce the number of smokers, and improve the total cholesterol could yield gains of 200,408, 198,173, 194,725, and 113,462 PALYs, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) حسب Connor, Izumi

"…CO2 is lost from the Gulf due to gas exchange, decreasing DIC, and reducing pCO2 to 464 μatm, similar to that observed. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Numerical analysis of spatial distribution of carbon in methane dry reforming over supported nickel catalyst in a packed bed reactor حسب Ebrahimi, Parisa

"…As the temperature increased, the total carbon deposition decreased, although this reduction became negligible beyond 850 °C. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 حسب Fiona B, Bennitt

"…FindingsIn 2021, 2·67 billion (95% uncertainty interval [UI] 2·63–2·71) people, 33·8% (95% UI 33·2–34·3) of the global population, were exposed to HAP from all sources at a mean concentration of 84·2 μg/m3. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic حسب Turki, O.

"…Higher stability of the ferroelectric (FE) phase was obtained at room temperature for the compositions y = 0.01, 0.02 and 0.05, with optimum values for y = 0.02 as remanent polarization Pr = 32µC/cm2, as well as piezoelectric coefficients d33 = 137 pC/N, kp = 0.27 and kt = 0.16, whereas a higher content of Dy (y = 0.08) induced a remarkable decrease of the ferroelectric and piezoelectric properties. …"
احصل على النص الكامل

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... حسب Salma, Younes

"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study حسب Houssein H., Ayoub

"…Increasing condom use from 10 % to 50 % lowers NG prevalence among FSWs, clients, and their spouses from 12.2 % to 6.4 %, 1.2 % to 0.5 %, and 0.4 % to 0.2 %, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Human health risks associated with the consumption of groundwater in the Gaza Strip حسب Basem, Shomar

"…Maximum concentrations of the NO3 and F were 365 and 2.6 mg/L, respectively. The results of probabilistic risk assessment using Monte Carlo simulation showed that NO3 and F consumption through drinking water were above the reference dose for 35 % and 5 % of the trials performed, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... حسب Alize J, Ferrari

"…Globally, HALE at birth improved slightly, from 61·3 years (58·6–63·6) in 2010 to 62·2 years (59·4–64·7) in 2021. However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. حسب Sara, Sokary

"…Also, it enhanced glycemic control, as evidenced by significant reductions in hemoglobin A1C (HbA1c) with the 0.5 mg and 1.0 mg doses. From a baseline range of 8.1–8.7%, 0.5mg dose lowered HbA1c by 1.2–1.5%, while the 1.0 mg dose reduced it by 1.4–1.8%. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021 حسب Eduardo, Bernabe

"…Furthermore, DALY rates of lip and oral cavity cancer decreased in the European region and the region of the Americas, while DALY rates of orofacial clefts decreased in all regions. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines حسب Najlah, Mohammad

"…Clinoleic loaded with paclitaxel decreased the viability of U87-MG cell to 6.4±2.3%, compared to Intralipid loaded with paclitaxel (21.29±3.82%). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 حسب Stein Emil, Vollset

"…The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5–6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2–26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [–0·6 to 3·6]). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل