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Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain
منشور في 2018"…Areas close to the stroke focus experienced decrease in the lipid and lipid acyl contents associated with an increase in lipid ester, olefin, and methyl bio-contents with a novel finding of Aβ1-42 in the PL-GM and L-WM. …"
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Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer
منشور في 2025"…Silencing LDHC in breast cancer cell lines (MDA-MB-468, BT-549, HCC-1954) enhanced early T cell activation and cytolytic activity. …"
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miRNA-dependent regulation of STIM1 expression in breast cancer
منشور في 2019"…<p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. …"
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
منشور في 2023"…Our results show that induction of SLFN11 expression can enhance DDA and DDR sensitivity in breast cancer cells and dCas9 systems may represent a novel approach to increase SLFN11 and achieve higher sensitivity to chemotherapeutic agents, improving outcome or decreasing required drug concentrations. …"
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Characterizing the Protein Coding RNAs (mRNA) and Long Non-Coding RNAs (LncRNAs) in Chemo Resistant Triple Negative Breast Cancer
منشور في 2023"…Breast Cancer (BC) is the most diagnosed cancer type in both genders according to the world health organization. …"
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Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis
منشور في 2017"…These findings suggest that mutation-driven perturbations of MAPK pathways are linked to the negative regulation of intratumoral immune response in breast cancer. Modulations of MAPK pathways could be experimentally tested to enhance breast cancer immune sensitivity.…"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…In the mouse model, R. coriaria at a higher dose (1%) significantly decreased tumor volume by 27% when compared to controls. …"
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Exploring the LDHC Interactome as Novel Candidate Therapeutic Targets to Advance Breast Cancer Precision Medicine
منشور في 2024"…</p><p dir="ltr">Finally, silencing of <i>PKM2 </i>and<i> TUBA1B</i> in breast cancer cells increased DNA damage and decreased cancer cell survival, validating their role in genomic integrity and mimicking our previous observations following silencing of LDHC. …"
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Meta-Heuristic Algorithm-Tuned Neural Network for Breast Cancer Diagnosis Using Ultrasound Images
منشور في 2022"…<div><p>Breast cancer is the most menacing cancer among all types of cancer in women around the globe. …"
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CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion
منشور في 2017"…While the exact function of CD146 in breast cancer (BC) is not completely understood, substantial evidence from our work and others support the hypothesis that CD146 is a suppressor of breast tumor progression. …"
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications
منشور في 2019"…In the TCGA TNBC/Basal-like cohort the <b><i>MAP3K21</i></b><b> </b><b>rs1294255-G</b> allele was associated with a decreased OVS. High expression of <i>CCL5</i> in breast tumors was significantly associated with an increased OVS in all BC patients, but particularly in TNBC/Basal-like patients. …"
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
منشور في 2024"…On the other hand, at the same time-on-stream LaNiMgO-Rh lost 0.3 and 0.7 % of its maximum CO2 and CH4 conversions, respectively.In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO2 conversion from 77.6 % to 70.5%, the CH4 conversion decreased from 72.3% to 64.2%. …"
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
منشور في 2024"…In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO<sub>2</sub> conversion from 77.6 % to 70.5%, the CH<sub>4</sub> conversion decreased from 72.3% to 64.2%. …"
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Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
منشور في 2021"…<p dir="ltr">Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors for breast cancer. However, cancer-related death remains high especially in triple-negative breast cancer (TNBC) due limited therapeutic options. …"
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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
منشور في 2019"…In this study, we analyzed CpG methylation of PD-L1 promoter in MCF-7 and BT-549 breast cancer cells and tumorspheres derived from them. …"
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
منشور في 2023"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. …"
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
منشور في 2019"…Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. To further identify the role of NRP-1 and its interacting molecules in correspondence with patients' response to neoadjuvant chemotherapy (NAC), we conducted a comparative study on blood and tissue samples collected from a cohort of locally advanced breast cancer patients, before and after neoadjuvant chemotherapy (NAC). …"
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BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells
منشور في 2020"…</p><h3>Results</h3><p dir="ltr">Treatment of human breast cancer cells with increasing concentrations of VCX caused a significant decrease in cells growth and proliferation. …"
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Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c...
منشور في 2024"…Results showed that ZNE and its Fraction 6 (F6) reduced the viability of MDA-MB-231 cells. F6 decreased MDA-MB-231 viability more than crude ZNE or its other fractions. …"