A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

The effects of a change in the point system on immigration حسب Chemin, Matthieu

"…In parallel, points for a subjective assessment of “adaptability” were decreased. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation حسب Robin Augustine (3976964)

Percutaneous coronary intervention can be safely performed with left ventricular thrombus without increasing stroke risk: A 5-year retrospective review using real-world data حسب Mohanad Shehadeh (17860691)

"…Therefore, in this study, we evaluated the risk of stroke among patients with LVT undergoing CAG +/− PCI.…"

Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy حسب Hanna, Rita

"…However, β2-AR receptors expression remained unchanged regardless of the disease stage. Moreover, we noted an early and specific upregulation of cardiac PDE1A, PDE2A, PDE4B, PDE4D and PDE5A expression at week 4, followed by increases in PDE3A levels in diabetic hearts at week 8. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). We then investigated the mechanism by which 5-Aza-CdR inhibits cell proliferation in the NCI–H1975 cell line. …"

What we do not know, hardly know, and really know about traffic safety حسب Leonard Evans (19773000)

"…This has never been, nor ever can be, experimentally examined. Likewise, we have no direct experimental investigation of how a driver’s crash risk increases with increasing speed. …"

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

SARS-CoV-2 Variants in Lebanon حسب Al Kodsi, Ibrahim

"…Genomes were generated using the artic nCoV-2019 bioinformatics protocol. We detected 53 Omicron subvariants, with XBB.1.5 (17.59%), XBB.1.42 (10.05%), and XBB.1.42.1 (9.05%), being the most common. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Boosting the visibility of services in microservice architecture حسب Ahmet Vedat Tokmak (17773479)

Thermoelectric power of (Cu0.5Tl0.5)-1223 superconducting phase added with BaSnO3 nanoparticles حسب Srour, A.

"…In this study, we report the thermoelectric power (TEP) measurements of Cu0.5Tl0.5Ba2Ca2Cu3O10-δ added with BaSnO3 nanoparticles. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis حسب HASHEM ABU SERHAN (19737499)

"…Three studies were included at 30 min and 2 studies at all other time points in the analysis. In vitrectomized eyes, notable decreases were observed: at 30 min, the Ratio of Means (ROM) was 0.81 (95% CI: 0.53; 1.24), indicating a 19% reduction; at 60 min, the ROM of 0.833 (95% CI: 0.77; 0.89) showed a 16.7% reduction; at 90 min, the ROM of 0.757 (95% CI: 0.755; 0.758) corresponded to a 24.3% reduction; at 2 h, the ROM of 0.726 (95% CI: 0.642; 0.820) reflected a 27.4% reduction; at 3 h, the ROM of 0.692 (95% CI: 0.600; 0.797) resulted in a 30.8% reduction; and at 4 h, the ROM of 0.700 (95% CI: 0.363; 1.350) indicated a 30% reduction. …"

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis حسب Milane, Aline

"…Expression and functionality of P-glycoprotein (ABCB1, P-gp) and Breast Cancer Resistance Protein (ABCG2, BCRP), two major efflux pumps, were studied. We observed an increased P-gp expression (1.5-fold) in presymptomatic mSOD1 mice compared to wild-type controls. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Phosphorus supplementation increases thermic response to glucose solution in healthy lean subjects حسب Bassil, Maya

"…Addition of P was associated with higher increase in VO2 (959±315 vs. 534±274 mL/60min; p= 0.03) which corresponded to higher TEF (5.7±1.6 vs. 3.6and±1.3kcal/60min; p=0.03 equivalent to 8% vs. 5% increase from RMR) during the first 60 min. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Surface microenvironment engineering of black V₂O₅ nanostructures for visible light photodegradation of methylene blue حسب Ahmed Badreldin (9574341)

"…<p dir="ltr">Utilization of photocatalysis as a promising strategy for environmental and energy applications has been widely considered. Herein, we report a novel black V₂O₅ material (bV₂O₅) synthesized using a controllable and environmentally benign physicochemical reduction method. …"

Exploring the epigenetic landscape: The role of 5-hydroxymethylcytosine in neurodevelopmental disorders حسب Mohamed Adil Shah Khoodoruth (14589828)

"…Moreover, we explore the implications of these findings for the development of epigenetic therapies aimed at modulating 5hmC levels. …"

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications حسب Sumama Nuthana Kalva (17302906)

"…PLA and WE43 composite filaments, containing various magnesium concentrations (5 %, 10 %, and 15 %), were produced using solvent evaporation and extrusion methods. …"

The Impact of Industry 5.0 Technologies on the Performance within the Healthcare Sector through the Integration of Gamification-Based Learning Programs حسب Alsuwaidi, Laila

احصل على النص الكامل

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 حسب Harshita Shailesh (14779408)

"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. …"