Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar حسب Chemaitelly, Hiam

"…In the post-first omicron phase, incidence rate of fatal COVID-19 decreased by 90.0% compared with earlier stages. Both severity and fatality exhibited an exponential increase with age and a linear increase with the number of coexisting conditions. …"
احصل على النص الكامل
احصل على النص الكامل

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Ganji, Vijay

احصل على النص الكامل
احصل على النص الكامل

Understanding the False Positive of Modified Martensitic Steels in Sweet & Sour Service Conditions Using a Point Defect Model Perspective حسب Martinez, Alan

"…These results indicate a critical point in temperature in the tests with only CO2, where resistance to pitting susceptibility is maximized due to a decrease in the cation vacancy diffusivity.…"
احصل على النص الكامل

A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact حسب Gowid, Samer

"…The results showed a decrease in the MSE of Vmp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of Imp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK حسب Patel, Shivalee

"…This study looks at the main stages of the food supply chain, and amasses the opportunities, challenges and trade-offs associated with surplus food redistribution to the UK economy. It highlights points in the food system where interventions can be made, to improve food’s circularity and sustainability potential. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells حسب Posadino, Anna Maria

"…Failure of PE to induce PC3 damage in cells overexpressing Akt further confirms its implication in the PE-elicited cell death. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effects of superelastic nano-NiTi additions on electroless Ni –P coating properties under bending حسب MacLean M.

"…In this study, electroless Ni –P-nano-NiTi composite coatings containing 5.14 wt%, 6.07 wt%, and 7.02 wt % NiTi were subjected to three-point bend testing in order to determine bending properties. …"
احصل على النص الكامل
احصل على النص الكامل

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines حسب Prabhu K.S.

"…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. …"
احصل على النص الكامل
احصل على النص الكامل

Generation, performance evaluation and control design of single-phase differential-mode buck-boost current-source inverters حسب Darwish, Ahmed

"…Since these inverters have continuous input currents, they are suitable for maximum power point tracking (MPPT) operation of photovoltaic systems. …"
احصل على النص الكامل
احصل على النص الكامل

Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway حسب Anwar, M. Akhtar

"…Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. …"
احصل على النص الكامل
احصل على النص الكامل

Signaling pathways activated by PACAP in MCF-7 breast cancer cells حسب Zibara, Kazem

"…Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …"
احصل على النص الكامل
احصل على النص الكامل

Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
احصل على النص الكامل
احصل على النص الكامل

A new family of boost active neutral point clamped inverter topology with reduced switch count حسب Siddique, Marif Daula

"…The neutral point is connected directly to the load terminals, which decreases the leakage current and makes it suitable for solar PV integration. …"
احصل على النص الكامل
احصل على النص الكامل

A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... حسب Thirumal Kumar, D

"…An extensive two-step molecular dynamics (simple and complex) simulation (MDS) using GROMACS (GROningen MAchine for Chemical Simulations) was then initiated to analyze and understand the structural impact of the E17K mutation on the function of AKT1. The simple MDS analysis revealed that the E17K mutation decreases the compactness and intramolecular hydrogen bonds of the protein. …"
احصل على النص الكامل
احصل على النص الكامل

Locations of Temporary Distribution Facilities for Emergency Response Planning حسب Pradhananga, Rojee

"…We assume that the individual demands in close vicinity are grouped at so-called aggregated demand points (ADPs). The distribution process initiates from a central supply point (CSP) which is a collection point that continuously acquires the resources and prepares them for distribution. …"
احصل على النص الكامل
احصل على النص الكامل

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway حسب Hadrich, F.

"…Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. …"
احصل على النص الكامل
احصل على النص الكامل

Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells حسب Zupin, L.

"…The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigation of solar PV performance under Doha weather using a customized measurement and monitoring system حسب Touati, Farid

"…Results predict that the maximum power output from a Poly-crystalline panel decreases by around 30% for a dust exposure of five months. …"
احصل على النص الكامل
احصل على النص الكامل

Pollution Characteristics of Particulate Matter (PM2.5 and PM10) and Constituent Carbonaceous Aerosols in a South Asian Future Megacity حسب Aslam, Afifa

"…Results of the study revealed that the mass concentration of PM2.5 and PM10 is at an elevated level throughout Faisalabad, with ambient PM2.5 and PM10 points that constantly exceeded the 24-h standards of US-EPA, and National Environment Quality Standards (NEQS) which poses harmful effects on the quality of air and health. …"
احصل على النص الكامل
احصل على النص الكامل

Impact of magnetic dipole on a thermally stratified ferrofluid past a stretchable surface حسب Muhammad N.

"…The analysis is disclosed by thermally stratified phenomenon and stagnation point. It is also noticed that the impact of magneto-thermomechanical coupling is inspected numerically via BVPh2 midpoint method. …"
احصل على النص الكامل
احصل على النص الكامل