Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK حسب Patel, Shivalee

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Dynamic workload patterns prediction for proactive auto-scaling of web applications حسب Iqbal W.

"…The framework is implemented and experimentally evaluated using historical access logs of three real web applications, each with increasing, decreasing, periodic, and randomly varying arrival rate behaviors. …"
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Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells حسب Posadino, Anna Maria

"…Failure of PE to induce PC3 damage in cells overexpressing Akt further confirms its implication in the PE-elicited cell death. …"
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Decreased soil moisture due to warming drives phylogenetic diversity and community transitions in the tundra حسب Scharn, Ruud

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Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines حسب Prabhu K.S.

"…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. …"
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Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway حسب Anwar, M. Akhtar

"…Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. …"
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Signaling pathways activated by PACAP in MCF-7 breast cancer cells حسب Zibara, Kazem

"…Moreover, selective inhibition of Src or PI3K resulted in a significant decrease in the phosphorylation of ERK and AKT, but not p38, demonstrating that PACAP signaling follows Src/Raf/ERK and PI3K/AKT pathways. …"
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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
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Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar حسب Chemaitelly, Hiam

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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... حسب Thirumal Kumar, D

"…An extensive two-step molecular dynamics (simple and complex) simulation (MDS) using GROMACS (GROningen MAchine for Chemical Simulations) was then initiated to analyze and understand the structural impact of the E17K mutation on the function of AKT1. The simple MDS analysis revealed that the E17K mutation decreases the compactness and intramolecular hydrogen bonds of the protein. …"
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Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway حسب Hadrich, F.

"…Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. …"
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A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact حسب Gowid, Samer

"…The results showed a decrease in the MSE of Vmp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of Imp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …"
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Effects of superelastic nano-NiTi additions on electroless Ni –P coating properties under bending حسب MacLean M.

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Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells حسب Zupin, L.

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Comprehensive thermoeconomic, exergoeconomic, and optimization analyses of direct oxy-combustion supercritical CO2 intercooled and reheated cycles under design and off-design condi... حسب Al-Ammari, Wahib A.

"…This study presents comprehensive energetic, exergetic, exergoeconomic, and economic (4E) performance analyses for four direct oxy-combustion (DOC) supercritical carbon dioxide (sCO2) power cycles at design, off-design, and part-load conditions. …"
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Thermal and mechanical characterization of injection moulded high density polyethylene/paraffin wax blends as phase change materials حسب Sotomayor, M.E.

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Driver Drowsiness Detection Study using Heart Rate Variability analysis in Virtual Reality Environment حسب Chowdhury, Muhammad E.H.

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Association between Insulin and Nitric Oxide in Human Retinal Microvascular Endothelial Cells in vitro حسب Rizk, Nasser Moustafa

"…Insulin treatment caused an up regulation of IRS-1 and IRS-2 genes after 1 hour however, PI3K, Akt and eNOS were significantly reduced. The analysis of angiogenic and proapoptotic markers VEGFA and NFkB by RT-PCR showed no significant change in the expression of NFkB in hyperglycemic alone, hyperglycemic and normoglycemic cells with insulin treatment at all-time points. …"
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Optimization of performance and emission characteristics of CI engine fueled with Jatropha biodiesel produced using a heterogeneous catalyst (CaO) حسب Singh, A.

"…The optimum performance and emission characteristics (BP, BTHE, HC and NOx) are found to be 2.258 KW, 29.05%, 6.31 ppm, and 159.5 ppm respectively. The performance of B20 fueled engine was almost comparable to that of diesel fuel. …"
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ASSOCIATION BETWEEN INSULIN RESISTANCE AND NITRIC OXIDE IN HUMAN RETINAL MICROVASCULAR ENDOTHELIAL CELLS IN VITRO حسب Bushra, Sumbul

"…This may suggest that insulin could counteract the hyperglycemic effect on AKT/PI3 kinase which mediates NO production and VEGF-A, with decreased adhesion molecules such as p-selectin that is involved in barrier disorder of retinal endothelial cells. …"
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