Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress حسب Hammad, Ayat Samir

"…Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). …"
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Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro حسب Hammad, Ayat S.

"…Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. …"
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Yerba Maté (Illex Paraguariensis) ingestion augments fat oxidation and energy expenditure during exercise at various submaximal intensities حسب Alkhatib, Ahmad

"…Results YM significantly increased FAO and EEFAO by 24% in all submaximal exercise intensities below 70% ofV˙O2peak (p < 0.001, ANOVA main effects) with post hoc tests showing a higher FAO and EEFAO (p < 0.05) at the lower exercise intensities (e.g. 0.26 ± 0.09 vs. 0.35 ± 0.10 and 0.25 ± 0.12 vs. 0.33 ± 0.11 g.min-1 at 40 and 50% ofV˙O2peak respectively). …"
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An experimental study on the effect of using gas-to-liquid (GTL) fuel on diesel engine performance and emissions حسب Bassiony, M. A.

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Dietary patterns and the risk of coronary heart disease among Jordanians: A case-control study. حسب Tayyem, R F

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AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro حسب Allouch, Soumaya

"…In contrast, metformin co-treatment restored the levels of phosphorylated AMPK, and suppressed activation of AKT and P70S6K in NRK-52E cells exposed to albumin. Notably, metformin also prevented albumin-induced EMT; this was marked by a 50% decrease in a-SMA and a 60% increase in E-cadherin expression. …"
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Salicylic acid restricts mercury translocation by activating strong antioxidant defense mechanisms in sweet pepper (Capsicum annum L.) حسب Khalid, Muhammad Fasih

"…So, the experiment was designed to assess the effect of SA on sweet pepper (Capsicum annum L.) seedlings grown under different Hg toxicity concentrations. Spraying of 100 μM SA at three different Hg levels, i.e., 0 μM, 50 μM, 100 μM, and 150 μM. …"
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Phenolic contents-based assessment of therapeutic potential of Syzygium cumini leaves extract حسب Ahmed, Rashid

"…The DPPH assay demonstrated a higher antioxidant potential (IC-50 value of 133 μg/ml), which was comparable to the IC-50 of ascorbic acid (122.4 μg/ml). …"
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Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model حسب Zakaria, Zain Z

"…Our data showed that AuNRs caused mortality with a calculated LC50 of EC50,24hpf of AuNRs being 9.1 μg/mL, while a higher concentration of AuNRs was revealed to elicit developmental abnormalities. …"
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Acute and chronic toxicity assessments of 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) on the calanoid copepod Acartia clausi: Effects on survival, development, sex-ratio and... حسب Emna, Djebbi

"…The most resistant life stage was N1 with LC50 values > 1500 μg L-1 and >5000 μg L-1, respectively for E2 and EE2. …"
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Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics حسب Nomikos, Michail

"…CaMQ136P protein exhibited a ∼7-fold reduced Ca2+-binding affinity compared to CaMWT, while CaMD132E had a ∼14-fold reduction. …"
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Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis حسب Smatti, Maria K.

"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations. Conclusion: Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"
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Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives حسب Zeiz, Ali

"…Anti-inflammatory assessments revealed that compound 1 displayed the strongest inhibitory activity on NO production with IC50 of 29.94 ± 2.24 µM, and down-regulated the expression of COX-2. …"
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Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. حسب Smatti, Maria K

"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations. Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"
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Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) حسب Connor, Izumi

"…Its values in the Gulf ranged from −50 to −310 μmol kg−1 implying CaCO3 precipitation. …"
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Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) حسب Connor, Izumi

"…Its values in the Gulf ranged from −50 to −310 μmol kg−1 implying CaCO3 precipitation. …"
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Specific Bioactive Compounds from Ginger, Tea, and Apple Prevent Diabetes-Related Cataract Via Inhibition of Aldose Reducatse حسب Ahmedna, Mohamed

"…The three compounds could inhibit AR activity up to 90 % at 12.5 μM of phloretin, EGCG and [6]-gingerol with IC50 values of 4.1 μM, 3.7 μM, and 2.4 μM, respectively. …"
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Theoretical and experimental insights into the C-steel aqueous corrosion inhibition at elevated temperatures in 1.0M HCl via multi-carbonyl Gemini cationic surfactants حسب El-Basiony, Nasser M.

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