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Decreased phosphodiesterase activities in cardiac hypertrophy
منشور في 2007"…Increased heart weight (43%) in the H group was accompanied by a general decrease in PDE activities in LV and a ≈ 50% reduction in PDE3 and PDE4. …"
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Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex
منشور في 2022"…<p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences <a href="https://dx.doi.org/10.3389/fmolb.2022.846996" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.846996</a>, published online 22 July 2022.…"
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Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer
منشور في 2017"…The cytotoxic effect of fractions (10, 25, 50 and 100 μg/mL) was tested on human epidermal keratinocytes (non-tumorigenic HaCaT cells and tumorigenic HaCaT-ras variants) using WST a ssay. …"
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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways
منشور في 2017"…HC showed a dose-dependent decrease in cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…Results β-2-himachalen-6-ol showed a dose-dependent decrease in cell survival with an IC50 and IC90 of 8 and 30 μg/ml, respectively. …"
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
منشور في 2018"…Papilloma yield, volume, histology, and mice weight and liver function were assessed. HC treatment decreased significantly cell survival (IC50 = 7 and IC90 = 40 μg/ml) and increased significantly cells undergoing late apoptosis and necrosis. …"
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β-2-himachalen-6-ol
منشور في 2016"…GC–MS and NMR spectroscopy revealed the identity of the major compound as β-2-himachalen-6-ol, a novel sesquiterpene unique to the Lebanese wild carrot. β-2-Himachalen-6-ol demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549 and SF-268 cancer cells (IC50 13–4 µg/ml; 58–18 µM), with SF-268 cells being the most sensitive. …"
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Intravitreal bevacizumab (Avastin) treatment of retinal angiomatous proliferation
منشور في 2008"…Six eyes underwent fluorescein angiography at the 12-week follow-up visit; 3 (50%) of these eyes had decreased leakage compared with baseline. …"
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Salicylic acid restricts mercury translocation by activating strong antioxidant defense mechanisms in sweet pepper (Capsicum annum L.)
منشور في 2023"…So, the experiment was designed to assess the effect of SA on sweet pepper (Capsicum annum L.) seedlings grown under different Hg toxicity concentrations. Spraying of 100 μ M SA at three different Hg levels, i.e., 0 μ M, 50 μ M, 100 μ M, and 150 μ M. …"
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
منشور في 2022"…Monotherapy with CBD demonstrated a dose-dependent tumor growth inhibition at 72h, with the IC50 being 12.5 μg/ml for OVCAR-3 cell line and 12.3 μg/ml for SK-OV-3 cell line. …"
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
منشور في 2008"…In the study described here, we tested that in mouse models WP1066, a novel STAT3 pathway blockade agent, has marked in vitro and in vivo activity, even with metastasis to the brain, a site typically refractory to therapies. WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against the human melanoma cell line A375, murine melanoma cell line B16, and B16EGFRvIII, respectively. …"
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Occurrence and removal characteristics of phthalate esters from bottled drinking water using silver modified roasted date pits
منشور في 2022"…The removal percentage was increased from 90 to 99% by increasing the temperature from 30 to 50 °C and then decreased to 92.3% at 60 °C.</p> <h2>Conclusion</h2> <p>RODP was successfully used as an effective adsorbent for phthalate esters removal from drinking water. …"
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Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf)
منشور في 2022"…Its values in the Gulf ranged from −50 to −310 μmol kg−1 implying CaCO3 precipitation. …"
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