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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …"
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…</p><h3>Conclusion</h3><p dir="ltr">Hypoglycemia potentiated both plasma sNRP1 level elevation and its ligands VEGF and SEMA3A, likely through an ADAM9-mediated mechanism that was not associated with RAS overactivity or ACEi therapy; however, whether this is protective or promotes increased risk for SARS-CoV-2 infection in T2D is unclear.…"
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The emergence of new SARS-CoV-2 variant (Omicron) and increasing calls for COVID-19 vaccine boosters-The debate continues
منشور في 2022"…<p dir="ltr">The emergence of highly mutated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has ushered panic responses around the world due to its contagious and vaccine escape mutations. …"
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Resection of liver metastases from breast cancer
منشور في 2012"…On multivariate analysis, estrogen receptor–negative primary breast disease (P = .009; hazard ratio, 3.3; 95% confidence interval, 1.4–8.2) and preoperative progressive disease (P = .003; hazard ratio, 3.8; 95% confidence interval, 1.6–9.2) were associated with decreased overall survival. …"
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Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain
منشور في 2018"…Areas close to the stroke focus experienced decrease in the lipid and lipid acyl contents associated with an increase in lipid ester, olefin, and methyl bio-contents with a novel finding of Aβ1-42 in the PL-GM and L-WM. …"
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Breast cancer cells and bone marrow mesenchymal stromal cells
منشور في 2017"…Interestingly, conditioned medium from co-cultures of MSCs and MDA-MB-231 cells significantly decreased the proliferation of activated T lymphocytes which was reversed by addition of anti-OPG antibodies to the co-cultures. …"
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Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer
منشور في 2025"…To gain a better understanding of the underlying mechanisms, comparative analysis of the effects of <i>LDHC</i> knockdown in cancer cell monocultures and co-cultures was conducted. Following <i>LDHC</i> knockdown, we observed an increase in the secretion of tumor-derived pro-inflammatory cytokines (IFN-γ, GM-CSF, MCP-1, CXCL1), a decrease in the soluble levels of tumor-derived immunosuppressive factors (IL-6, Gal-9) and reduced tumor cell surface PD-L1 expression. …"
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Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells
منشور في 2021"…Residual ASS1 tumor expression corelated with increased metastasis and decreased survival in patient luminal A, Her2+ and triple-negative breast cancer. …"
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masterThesis -
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CO, CO2, and SO2 detection based on functionalized graphene nanoribbons: First principles study
منشور في 2020"…Before modification, the adsorption energies have been found to be −0.260, −0.145, and −0.196 eV due to the adsorption of CO, CO2, and SO2, respectively. After modification, the adsorption energy increased remarkably to −0.538 and −0.767 eV for the cases of AGNR-O-OH-CO2 and AGNR-O-OH-SO2, respectively. …"
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AI avatars and co-creation in the metaverse
منشور في 2025"…Findings Based on data triangulation, the extracted themes dealt with four key areas: (1) avatars’ relational encounters in hospitality, (2) avatars’ realism, (3) self-representation and self-perception skewness and (4) AI co-creation. The findings show that while avatars’ realism would increase the authenticity of virtual social connections, engagement and monetization, the issue of a self-misrepresentation will diminish the effect of virtual encounters. …"
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miRNA-dependent regulation of STIM1 expression in breast cancer
منشور في 2019"…<p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. …"
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Pt-doped armchair graphene nanoribbon as a promising gas sensor for CO and CO2: DFT study
منشور في 2020"…Moreover, an increase of almost 13 times was observed in the adsorption energy for the case of CO on Pt–H-AGNR. …"
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
منشور في 2023"…Our results show that induction of SLFN11 expression can enhance DDA and DDR sensitivity in breast cancer cells and dCas9 systems may represent a novel approach to increase SLFN11 and achieve higher sensitivity to chemotherapeutic agents, improving outcome or decreasing required drug concentrations. …"
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Drivers of MERS-CoV Emergence in Qatar
منشور في 2018"…The transition in husbandry leading to high density camel farming along with increased exposure to humans, combined with the increase of camel movement for the racing and breeding industry, have led to a convergence of factors driving spillover of MERS-CoV from camels to humans.…"
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Salesperson moral identity and value co-creation
منشور في 2022"…This process facilitates the mechanisms for salesperson moral identity centrality to decrease selling orientation and increase customer orientation and value co-creation, leading to higher sales performance. …"
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SARS-CoV-2 Variants in Lebanon
منشور في 2024"…Variants of concern (VOC) included Alpha, Beta, Delta, Gamma, and most recently Omicron. Co-infections of SARS-CoV-2 with influenza viruses were detected and led to increased infectivity and SARS-CoV-2 viral load. …"
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masterThesis -
19
Pt-doped armchair graphene nanoribbon as a promising gas sensor for CO and CO<sub>2</sub>: DFT study
منشور في 2021"…Moreover, an increase of almost 13 times was observed in the adsorption energy for the case of CO on Pt–H-AGNR. …"
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
منشور في 2020"…Breast cancer-related deaths are mostly due to breast cancer invasion and migration to distant secondary regions. …"
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masterThesis