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Decreased phosphodiesterase activities in cardiac hypertrophy
منشور في 2007"…Cyclic nucleotide-gated (CNG) channels were used to monitor cAMP. The whole cell patch-clamp technique was used to record the associated CNG current (ICNG) and ICa,L. …"
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Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers
منشور في 2022"…To reuse the leakage-inductor (LI) energy of the CI with the help of a passive clamp circuit for reducing the voltage stress across the switch, similarly switch has less resistance so conduction losses also decreased. …"
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Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals
منشور في 2009"…Engineered cyclic nucleotide-gated (CNG) channels were expressed in single cardiomyocytes to monitor subsarcolemmal cAMP using whole-cell patch-clamp recordings of the associated CNG current (ICNG). …"
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Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hype...
منشور في 2023"…The hyperinsulinemic euglycemic clamp (HIEC) is the gold standard for the assessment of insulin sensitivity (IS). …"
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Subsarcolemmal cAMP signals monitored by cyclic nucleotide gated channels in hypertrophied cardiac myocytes
منشور في 2005"…This channel is gated by cAMP and thus allow to follow cAMP dynamics by recording the associated cationic current (ICNG) with the whole cell patch clamp technique 24 h after infection. Cumulative concentrationresponse curve to the non-selective E-adrenergic agonist isoprenaline (Iso) indicated a 33% decrease of the maximal cAMP accumulation produced by Iso while the effect of the hydrosoluble forskolin analog, L-858051 at a saturating concentration (100 µM) was unchanged between the two groups. …"
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Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19
منشور في 2021"…OT2D subjects underwent hyperinsulinemic clamp to normalize serum glucose. Plasma macrophage-related proteins were determined using Slow Off-rate Modified Aptamer-scan plasma protein measurement at baseline (control and OT2D subjects) and after 1-h of insulin clamp (OT2D subjects only). …"
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Evaluation of Lycopus uniflorus water extract for anti-inflammatory, anti-ulcerogenic and antioxidant activities
منشور في 2009"…Results showed that 50mg/kg and 100mg/kg caused 20.87 and 80.10%, respectively, compared to 41.70% for cimetidine at 11.5mg/kg BW dose. …"
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Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia
منشور في 2021"…We performed a case–control induced hypoglycemia clamp study, maintaining blood glucose at 2.8 mmol/L (50 mg/dL) for 1 h in 17 subjects (T2D (n = 10); controls (n = 7)). …"
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Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity
منشور في 2021"…</p><h3>Methods</h3><p dir="ltr">A prospective, parallel study in T2D (n = 23) and controls (n = 23). A hyperinsulinemic clamp was performed and normoglycemia induced in T2D [4.5 ± 0.07 mmol/L (81 ± 1.2 mg/dl)] for 1-h, following which blood glucose was decreased to ≤2.0 mmol/L (36 mg/dl). …"
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…</p><h3>Methods</h3><p dir="ltr">A case-control study of aged-matched T2D (n = 23) and control (n = 23) subjects who underwent a hyperinsulinemic clamp over 1-hour to hypoglycemia(<40mg/dl) with subsequent timecourse of 4-hours and 24-hours. …"
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Effect of structural remodeling (retraction and recoil) of the pipeline embolization device on aneurysm occlusion rate
منشور في 2014"…The diameter and length of the Pipeline Embolization Device were measured at both time points and compared for determination of the device changes. …"
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Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS
منشور في 2018"…Before and after the exercise program, all participants underwent hyperinsulinaemic euglycaemic clamps with either saline or intralipid infusions. …"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…With this potential for improving patient outcomes, decreasing costs, and facilitating nursing care and catheter management, the use of PPV devices becomes both advantageous and desirable. …"
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Metabolomics of Dynamic Changes in Insulin Resistance Before and After Exercise in PCOS
منشور في 2019"…IS was lower in PCOS (p < 0.001) and was further decreased by the lipid infusion in both PCOS and controls. …"