Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer حسب Mariam Abotaleb (18808261)

"…In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. …"

TRPV2: A Cancer Biomarker and Potential Therapeutic Target حسب Kodappully S. Siveen (4246150)

"…In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis. Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death. …"

Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications حسب Gulab Sher (12984698)

"…<p dir="ltr">The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. …"

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis حسب Milane, Aline

"…We observed an increased P-gp expression (1.5-fold) in presymptomatic mSOD1 mice compared to wild-type controls. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Prophylactic and therapeutic antibiotic patterns of lebanese dentists for the management of dentoalveolar abscesses حسب Mokhbat, J.

"…The main prescribed antibiotic was amoxicillin.This study showed that dentists often did not follow the current prophylactic and therapeutic antibiotic prescription guidelines.Antibiotics prescriptions in dentistry will be more pertinent, leading to a decrease in inadequacy of prescriptions, microbial resistance, and the development of multiresistant germs against antibiotics…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors حسب Naila Rabbani (291722)

"…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …"

Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment حسب Alanod D. AlQahtani (18805930)

"…These two techniques improve stability, reduce immunogenicity, and increase drug resistance to proteases. These factors lead to the reduction of injection frequency which increases patient compliance and improve quality of life. …"

Effect of methanolic extract of Quercus infectoria bark on blood lipid profile, glycemia, inflammation, platelet aggregation, ulcer and bacterial activity. (c2005) حسب Khouzami, Lara

احصل على النص الكامل
احصل على النص الكامل

The effects of daucus carota extracts on different body functions, inflammation, induced gastric ulcer in rats and bacterial growth. (c2005) حسب Abdallah, Katia Wehbe

احصل على النص الكامل
احصل على النص الكامل

FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets حسب Reem Saleh (3513056)

"…We also describe potential therapeutic strategies to target Tregs in combination with other types of immunotherapies aiming to overcome tumor resistance and improve clinical outcomes in cancer patients. …"

The changing landscape in the treatment of metastatic castration-resistant prostate cancer حسب El Amm, Joelle

"…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions حسب Sama Ayoub (15430987)

"…<p dir="ltr">As global life expectancy increases, the prevalence of neurodegenerative diseases like Alzheimer’s disease (AD) continues to rise. …"

Metabolic signature of obesity-associated insulin resistance and type 2 diabetes حسب Haya Al-Sulaiti (5449256)

"…</p><h3>Conclusion</h3><p dir="ltr">This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. …"

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance حسب Ajaz A. Bhat (12984701)

Effect of water extract of Althaea officinalis flowers on inflammation, gastric ulcer, bacterial activity, platelet aggragation, glycemia, and lipidemia. (c2006) حسب Hage-Sleiman, Rouba

احصل على النص الكامل
احصل على النص الكامل

Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy حسب Al Bostami, Rouba D.

احصل على النص الكامل

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance حسب Gh Rasool Bhat (13038132)

"…This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. …"

Therapeutic Impact of P-PENT, P-HEX and 5CLSS (IV) Platinum (IV) complexes on Acute Myeloid Leukemia in vitro and in vivo حسب Bou Chacra, Joelle

"…Platinum (II)-based complexes, such as cisplatin and carboplatin, are widely known for their anticancer activity against various types of cancers. While resistance has limited their efficacy, a growing interest in platinum (IV) complexes has recently grown to overcome this challenge. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) حسب El Jawhari, Yassmine

"…Hence, HuArgI (Co)-PEG5000 is an efficient and selective therapeutic method for targeting GBM.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) حسب Khalil, Nathalie

"…Normal cells, on the other hand, were resistant to HuArgI (Co)-PEG5000-induced arginine deprivation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل