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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…We investigated protein glycation and oxidative damage in skeletal muscle of mice with UCP1 expression under control of the human skeletal actin promoter (HSA-mUCP1) at age 12 weeks (young) and 70 weeks (aged). We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…We investigated protein glycation and oxidative damage in skeletal muscle of mice with UCP1 expression under control of the human skeletal actin promoter (HSA-mUCP1) at age 12 weeks (young) and 70 weeks (aged). We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …"
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Effectiveness of 2D magnesium phosphate hydrogel for surgical decontamination of dental implants: A case series
منشور في 2024"…<p dir="ltr">Dental implants, recognized for their enhanced functionality and aesthetic outcomes, are susceptible to peri‐implant mucositis and subsequent peri‐implantitis when oral hygiene is inadequate. …"
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Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030)
منشور في 2024"…This study aimed to model past, present, and future LULCC on Land Surface Temperatures in the Greater Amman Municipality (GAM) in Jordan between 1980 and 2030. …"
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Assessment of tropospheric NO<sub>2</sub> concentrations over greater Doha using Sentinel-5 TROPOspheric monitoring instrument (TROPOMI) satellite data: Temporal analysis, 2018–202...
منشور في 2024"…<p dir="ltr">This study presents a temporal evaluation of the tropospheric NO<sub>2</sub> column densities over Greater Doha using TROPOMI satellite data from May 2018 to December 2023, and an assessment of the impact of the preparations and hosting of the FIFA Football World Cup Qatar 2022, on NO<sub>2</sub> levels before, during and after the tournament over Greater Doha. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Nickel toxicology testing in alternative specimen from farm ruminants in a urban polluted environment
منشور في 2024"…Soil with the minimum nickel level was found under C. decidua while the maximum concentration was reached under the A. nilotica. …"
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Visitors off the trail: Impacts on the dominant plant, bryophyte and lichen species in alpine heath vegetation in sub-arctic Sweden
منشور في 2021"…With a greater decrease in taller forbs and shrubs than in graminoids and prostrate plants, a greater decrease in lichen than in bryophyte species, and a change in vegetation composition. …"
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Rebound effects undermine carbon footprint reduction potential of autonomous electric vehicles
منشور في 2023"…<p dir="ltr">Autonomous vehicles offer greater passenger convenience and improved fuel efficiency. …"
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Life cycle assessment of compressed air, vanadium redox flow battery, and molten salt systems for renewable energy storage
منشور في 2021"…It is also found that the production stage of the storage systems accounts for the highest share of carbon footprint.…"
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Characterizing the dynamics of climate and native desert plants in Qatar
منشور في 2024"…These findings suggest a continued decrease in vegetation coverage, leading to more drought seasons and impacting water and food security. …"
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Board Characteristics and Bank Stock Performance: Empirical Evidence from the MENA Region
منشور في 2024"…This suggests that banks with fewer board members and high independence levels have their shares outperforming others. However, we found that having frequent board meetings per year and separate roles for the CEO and chairman have no impact on bank stock performance. …"
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Evidence-based safety education and training for traffic injury prevention
منشور في 2015"…Bicycle skill training for children and youth may increase their safety knowledge, but not necessarily improve their behavior or decrease their injury rates. Non-legislative interventions were found effective for increasing observed helmet use among bicyclists. …"
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Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (<i>Dicentrarchus Labrax</i>)
منشور في 2024"…Fish fed with CURNPS at various levels exhibited remarkable increase in digestive enzymes (amylase and lipase), immune markers (immunoglobulin G (IgG), lysozyme and phagocytic indices), and antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)). A noticeable decrease (P<0.05) in malondialdehyde (MDA) and considerable upregulation of hepatic insulin-like growth factor 1 (IGF1) and interleukin-1beta (IL-1β) mRNA levels were found in CURNPs-supplemented fish in a dose-dependent manner. …"
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
منشور في 2019"…</p><h3>Results</h3><p dir="ltr">In our sample of 11,784 persons, we found 10 medical symptoms that predicted AA information seeking and 9 symptoms that predicted NA information seeking. …"
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Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer
منشور في 2024"…We demonstrated an increase in immune cell density and a decrease in the distance of CD3<sup>+</sup>CD8<sup>+</sup> T cells to the nearest tumor cell, in the immune active, ICR High, immune subtypes. …"
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Investigation of the Sustainable Production and Utilization of Biochar and Activated Carbon From Waste
منشور في 2023"…Out of the activated biochars tested, those produced without catalyst at 600 °C using either 2M KOH or 2% H<sub>3</sub>PO<sub>4</sub> at a ratio of 1:1 of SCG were found to be the most efficient adsorbents with a BET surface area greater than 340 m<sup>2</sup> .g<sup>-1</sup>, zeta potential of more than -75 mV and fixed carbon of 65%. …"
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Groove Pancreatitis Associated with Transient Liver Injury Mimicking Ampullary Neoplasm
منشور في 2020"…We report a 52-year-old male smoker with hypertension, asthma, and alcohol abuse who was admitted with severe epigastric pain radiating to the back. He was found to have acute pancreatitis. A computed tomography scan of the abdomen showed a mass lesion in the peri-ampullary region. …"