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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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New susceptibility loci associated with type 2 diabetes. (c2011)
منشور في 2011احصل على النص الكامل
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masterThesis -
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Natural resource dependence and war nexus: new insights
منشور في 2025"…Using a panel probit model, we find that natural resources rents, military expenditures, and the presence of a common law tradition significantly increase the probability of war occurrence. …"
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article -
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Successive interference cancellation using stage dependent decision functions
منشور في 2004"…In this paper, we introduce the concept of stage-dependent decision functions. The latter exploit the improvement of the soft-decisions' reliability with increasing number of stages to take more hard-decisions and thus cancels more noise from stage to stage. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Metabolic Profiling of Exercise-induced Autophagy-dependent Metabolites in Mouse Plasma
منشور في 2024"…Our results show that exercise induced distinct metabolic changes in mouse plasma, with several metabolites, including pregeijerene, androsterone glucuronide, meproscillarin, and N-acetyl methionine, showing significant increases in the exercise group. These changes were largely attenuated by CQ treatment, suggesting their dependence on autophagy. …"
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masterThesis -
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
منشور في 2020"…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …"
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Serviceability and Flexural Behavior of Concrete Beams Reinforced with Basalt Fiber-Reinforced Polymer (BFRP) Bars Exposed to Harsh Conditions
منشور في 2020"…Test results also indicate that increasing the reinforcement ratio did not result in a directly proportional increase in the moment capacity. …"
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Effects of Social Media Use and Dependence on Dietary Intake and Prevalence of Orthorexia in Pregnant and Non-Pregnant Women
منشور في 2022"…A mixed-method design was used. Participants (250 pregnant and 240 non-pregnant Lebanese women) filled a questionnaire assessing social media use and dependence, intuitive eating behaviors as well as orthorexia. …"
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masterThesis