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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
منشور في 2023"…<h3>Objectives</h3> <p>To explore the influence of ambient temperature and humidity on significant bacteriuria (SB) and urinary bacterial isolates in pregnant women.…"
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An integrative comparative study between ultrasound-guided regional anesthesia versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: A...
منشور في 2022"…However, parenteral opioids are subjected to several adverse effects. New pain management techniques such as regional anesthesia are used as alternatives to parenteral opioids. …"
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Effect of the presence of pre-service construction cracks in concrete decks on the thermal profile of composite steel-concrete bridges in cold regions
منشور في 2017"…Thermally induced stresses in composite steel-concrete bridges are higher than those experienced by their concrete and steel cousins, leading to significant damage in the concrete deck and corrosion of the steel reinforcement. …"
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
منشور في 2011"…After careful analysis of response from principals, it was identified that student learning via PDPs is considered an essential activity by schools in this region. Unfortunately, the end results of such programs are not as effective as desired for several reasons. …"
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Economic development and sub-regional identities
منشور في 2015"…The results indicate that explanatory variables responded differently in each group, which indicates the significant effect of the identities used to determine the division of the regions. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Investigating the Effectiveness and Teachers’ Perceptions of Rigorous Curriculum Design for Project-Based Learning Implementation on Middle School Science Students’ Achievement and...
منشور في 2023"…Therefore, further research is suggested with regards to monitoring the effectiveness of RCD-PBL on MAP scores for more than one academic year, investigating the effectiveness of such curricula in different subjects, grade levels, and impact on genders, increasing parental involvement, and examining their perceptions towards such curriculum design…"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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