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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
منشور في 2021"…However, DCM was not associated with changes in PDE4A gene expression irrespective of the disease stage. Significance We show for the first time differential and time-specific regulations in cardiac PDEs, data that may prove useful in proposing new therapeutic approaches in T1D-induced DCM.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Characterization of exercise-induced hemolysis in endurance horses
منشور في 2023"…Blood plasma was collected before and after the competition and analyzed macroscopically, by ELISA and non-targeted metabolomics with liquid chromatography–mass spectrometry. A significant increase in all hemolysis parameters was observed after the race, and an association was found between the measured parameters, average speed, and distance completed. …"
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
منشور في 2022"…<p>Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. …"
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Local arterial vasoconstriction induced by octreotide in patients with cirrhosis
منشور في 2000"…FBF in the control arm was unchanged despite a significant decrease in systemic glucagon levels. Methacholine infusion increased FBF around 300%, which was not altered by the concomitant infusion of octreotide. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…Flow cytometric analysis revealed that both fractions induced the accumulation of cells in the sub-G1 phase, increase in apoptotic cell death and chromatin condensation. …"
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Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report
منشور في 2025"…Our patient's symptoms significantly improved with propranolol and carbimazole treatment. …"
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The effects of Cucurbita pepo seeds on testosterone induced benign prostatic hyperplasia
منشور في 2011"…Additionally, no significant effects were observed on levels of sGOT-AST enzyme and ALP, while slight increase was observed on sGPT-AST. …"
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Fermentation-induced modifications to the structural, surface, and functional properties of quinoa proteins
منشور في 2025"…Notably, fermentation significantly increases the digestibility of QPs from 78.13 to 85.24%, thereby enhancing their nutritional value. …"
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Metabolic Profiling of Exercise-induced Autophagy-dependent Metabolites in Mouse Plasma
منشور في 2024"…Our results show that exercise induced distinct metabolic changes in mouse plasma, with several metabolites, including pregeijerene, androsterone glucuronide, meproscillarin, and N-acetyl methionine, showing significant increases in the exercise group. …"
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masterThesis -
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
منشور في 2023"…The use of a CRISPR-dCas9 UNISAM and KRAB system could increase or decrease SLFN11 expression significantly (up to fivefold), stably and specifically in BT-549 and T47D cancer cell lines. …"
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Phosphorus supplementation recovers the blunted diet-induced thermogenesis of overweight and obese adults
منشور في 2016"…Overweight/obese subjects had a blunted DIT with placebo, while P supplementation induced a 23% increase in their DIT area under the curve (p < 0.05), which was associated with a significant increase in carbohydrate oxidation. …"
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
منشور في 2020"…Mechanical stretch significantly increased p-ERK1/2 after 10 minutes, whereas APN significantly reduced stretch-induced ERK1/2 phosphorylation. …"
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
منشور في 2000"…However, when ultrasound was applied, a rapid and significant increase in DNA damage was observed (P=0.0001). …"
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