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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Choline chloride based natural deep eutectic solvent for destabilization and separation of stable colloidal dispersions
منشور في 2021"…NADES showed the most efficient performance with almost 100% turbidity removal and a significant reduction in the zeta potential of − 18 mV. …"
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Developments in Chemical Treatments, Manufacturing Techniques and Potential Applications of Natural-Fibers-Based Biodegradable Composites
منشور في 2021"…Chemical treatments and surface modifications can improve the quality of the natural fibers. Natural-fiber-based composites are a potential candidate for many lightweight engineering applications with significant mechanical properties. …"
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Key determinants of SMEs’ export performance: a resource-based view and contingency theory approach using potential mediators
منشور في 2020"…</p><h3>Design/methodology/approach</h3><p dir="ltr">This study draws on contingency theory and takes a resource-based and market-based view to provide a holistic understanding of the issue. …"
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Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma
منشور في 2015"…Also, there was a dose-dependent decrease in papilloma yield during the study period. …"
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A Meta-Analysis to Gauge the Effectiveness of STEM Informal Project-Based Learning: Investigating the Potential Moderator Variables
منشور في 2023"…<div><p>In recent decades, informal project-based learning (PjBL) for science, technology, engineering, and mathematics (STEM) education has gained immense significance. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Potential Medical Applications of Chitooligosaccharides
منشور في 2022"…This review aims to outline the recent advances and potential applications of COS in various diseases and conditions based on the available literature, mainly from preclinical research. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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