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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Predicting Mobile Game Success Using Data Analytics
منشور في 2017"…The most successful game predictions were extracted and compared to the predominating user behaviors for further analysis and implications. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Predictive Power of Random Forests in Analyzing Risk Management in Islamic Banking
منشور في 2024"…Analyzing risk-related concerns, the study notes a significant reduction in credit portfolio risk attributed to improved risk management practices, global economic growth, stricter regulations, and diversified asset portfolios. …"
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Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
منشور في 2021"…This study aims to characterize PDB-associated changes in DNA methylation profiles in patients’ blood. Meta-analysis of data from the discovery and cross-validation set, each comprising 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions. …"
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Metabolomics-based prediction model for diabetes: A comprehensive analysis of biomarkers and machine learning approaches
منشور في 2025"…</p><h3>Results</h3><p dir="ltr">Among 450 individuals, 9.33 % (n = 42) were diagnosed with diabetes. Correlation analysis identified 140 metabolites significantly associated with diabetes status (p < 0.05). …"
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis
منشور في 2021"…The CGM data have been rigorously investigated, and pertinent features were created along with a multi-stage multi-class (MSMC) classification model to predict futuristic HbA1c levels. To evaluate the developed framework, a total of 150 patients' data were sourced from Sidra Medicine, Doha, Qatar, for analysis. …"
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Prediction of pressure gradient for oil-water flow: A comprehensive analysis on the performance of machine learning algorithms
منشور في 2022"…A Friedman's test and Wilcoxon Sign-Rank post hoc analysis with Bonferroni correction show that PG prediction errors using GP are significantly lower than using the ANN model (p < 0.05). …"
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Explainable machine learning model and reliability analysis for flexural capacity prediction of RC beams strengthened in flexure with FRCM
منشور في 2022"…The predicted flexural and load capacities of the beams based on the existing analytical models are highly scattered and either over-conservative or unsafe. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…The computational results demonstrate the superiority of the proposed models through a comparative analysis against state-of-the-art approaches across fifteen significant wave height time series, validated by three error metrics and a statistical test.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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