Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…<p dir="ltr">Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. …"

Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy حسب Olfa Khalifa (10914452)

"…Analysis of the Oil Red O staining showed that Ex-4 significantly reduces steatosis. This reduction was confirmed by FTIR analysis, as the phospholipid band (C=O) at 1740 cm−1 in Ex-4 treated cells is significantly decreased compared to steatotic cells. …"

Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation حسب Rizk, Sandra

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Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases حسب Glazer, Evan

"…Main Outcome Measures To determine the accuracy of PET scans to detect residual viable colorectal cancer liver metastases after a significant response to systemic chemotherapy. …"
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Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases حسب Shin Chun, Yun

"…Conclusion Among patients with colorectal liver metastases treated with bevacizumab-containing chemotherapy, CT-based morphologic criteria had a statistically significant association with pathologic response and overall survival.…"
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Human hepatic stellate cells and inflammation حسب Faour, Wissam H.

"…Within this context, human liver stellate cells (HSC) demonstrated marked immunological plasticity that has main importance for future liver cell therapy application. …"
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Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases حسب Ribero, David

"…The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver histology. …"
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... حسب Masri, Oussama Samer

"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... حسب Mohamed Yassin (4166515)

"…The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. The HOPE trial demonstrated a 51 % improvement in hemoglobin response and a reduction in hemolytic markers in patients treated with voxelotor. …"

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors حسب Mashael Al-toub (3563303)

"…<p>The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. …"

Immuno-biological comparison of hepatic stellate cells in a reverted and activated state حسب Faour, Wissam H.

"…In conclusion, the immunologic profile of HSCs is significantly modulated by their activation state and inflammation and is important for the development of novel HSC liver cell-based therapy.…"
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Anticancer Effects of Lebanese Cannabis Oil Against in vivo and in vitro Models of Squamous Cell Carcinoma حسب Azar Atallah, Shirine

"…Intraperitoneal treatment of mice with COE (10, 25 or 50 mg/kg; 9 weeks) showed a non-significant decrease in tumor volume with respect to control, without adverse effects on liver and kidney function. …"
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Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells حسب Abi-Habib, Ralph J.

"…However, the primary dose-limiting side effect is liver toxicity. We have reproduced liver toxicity in rats using the rodent cell-tropic DT-murine GMCSF (DT390mGMCSF). …"
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A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours حسب Fateen Ata (12217764)

"…The recovery rate was 77%, with chronic liver disease (CLD) significantly associated with a poor outcome (OR: 7.23, P: 0.03). …"

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease حسب Inati, Adlette

"…Direct determination of liver iron concentration (LIC) was performed using R2 MRI. …"
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Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa حسب Fatiha Seglab (22468265)

"…In addition, leaves methanolic extracts (IVLM) caused the highest reduction in viability of A549 cells among all the extracts. IVLM also reduced the viability of human ovarian SK-OV-3, breast MCF-7, liver HepG2, and colorectal HCT116 cancer cells. …"

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism حسب Khaoula Errafii (10914446)

"…Furthermore, 1644 DEGs were identified between steatotic cells and Ex-4-treated cells, with liver X receptor/retinoid X receptor (LXR/RXR) (p = 2.02 × 10⁻⁷) and FXR/RXR (p = 3.28 × 10⁻⁷) activation being the two top canonical pathways. …"

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…Moreover, MALAT1 knockdown dramatically suppressed oleic-induced lipid accumulation in HepG2 cells. Interestingly, knocking down MALAT1 significantly reduces the expression of CD36 in steatosis HepG2 cells in the presence of Ex-4. …"

The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review حسب Mahmoud Yousef (9900837)

Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4 حسب Khaoula Errafii (10914446)

"…<h3>Background and aims</h3><p dir="ltr">The hallmark of non-alcoholic fatty liver disease (NAFLD) is the excessive hepatic lipid accumulation. …"