The Effect of Different Doses of Intravenous Dexmedetomidine on the Properties of Subarachnoid Blockade: A Systematic Review and Meta-Analysis حسب Mohammad K Al Nobani (16561248)

"…We analyzed the duration of sensory and motor blockade and the related adverse effects in relation to different doses of IV dexmedetomidine.</p><p><b>Results:</b> Intravenous dexmedetomidine, with loading dose of 1 mcg/kg, prolonged the sensory blockade duration of spinal anaesthesia by a mean difference of 49.6 min, P<0.001, and motor blockade duration by a mean difference of 44.7 min, P<0.001, while a loading dose of 0.5 mcg/kg prolonged the sensory blockade by a mean difference of 43.06 min, P<0.001, and motor blockade duration by a mean difference of 29.09 min, P<0.001. …"

Effect of age and sex on warfarin dosing حسب Khoury, Ghada

"…The primary outcome assessed was warfarin total weekly dose (TWD). Results There was a statistically significant difference in the TWD among the ages (P<0.01); older patients required lower doses. …"
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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants حسب Saad, Aline

"…By bringing similarities and differences among these agents and their potential interactions to clinicians’ attention, they can appreciate and apply these findings in a individualized patient approach rather than follow only the one-size-fits-all dosing recommendations suggested in many tertiary references. …"
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Investigating the Effect of Patient-Related Factors on Computed Tomography Radiation Dose Using Regression and Correlation Analysis حسب AlShurbaji, Mohammad

"…Investigating the relationships between the different dose indices, statistically significant relationships were found between all dose indices. …"
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Enoxaparin dosing for venous thromboembolism prophylaxis in hospitalized underweight adult patients: a retrospective cohort study حسب Salam Ibrahim Abou Safrah (21264303)

"…</p><h3>Conclusion</h3><p dir="ltr">There is no significant difference in the incidence of bleeding or VTE between the reduced dose and the standard dose of enoxaparin for VTE prophylaxis in underweight adult patients. …"

A comparative single-dose bioequivalence study of two Glibenclamide brands among healthy volunteers. (c2000) حسب Tannous, Elias Fouad

"…Furthermore, the difference between area under serum concentration-time curve (AUC) for the two products ( 390.86 ± 152.61 and 360.7 ± 160.21 ng hr Iml for A and B, respectively) was not statistically significant, with P > 0.05. …"
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A comparative single-dose bioequivalence study of two enteric coated Aspirin brands among healthy volunteers. (c2001) حسب Zeitoun, Abeer Abbas

"…Moreover, there was no statistically significant difference with respect to peak serum concentration (The Cmax values for Aspicot® (23,66 ± 16,26 ~g / mL) and Aspirin Protect® (21.73 ± 11.33 ug / mL) or to corresponding peaks time (the Tmax values ( 4,92 ± 2.35 hours and 4,58 ± 1,5 1 hours for Aspicot® and Aspirin Protect® respectively), Furthermore, the difference between area under the serum concentration time curve for the two products (the AUC for Aspicot® (66,20 ± 42,90 ug / mL) and Aspirin Protect® (64,79 ± 38,02 ug / mL) was not statistically significant, with P > 0,05. …"
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Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro حسب Khalife, Rana

"…The reduction in proliferation was significantly dose- and time-dependent. After determining the best combination (40 µM thymoquinone and 0.6 µM topotecan), cell proteins were extracted after treatment, and the expression levels of B-cell lymphoma 2 and of its associated X protein, proteins p53 and p21, and caspase-9, caspase-3, and caspase-8 were studied by Western blot. …"
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Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles حسب El Maarri, Osman

"…Previously, we reported on inter-individual and gender specific variations of LINE-1 methylation in healthy individuals. …"
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Effect of high dose vitamin D supplementation on indices of sarcopenia and obesity assessed by DXA among older adults: A randomized controlled trial حسب Jabbour, Jana

"…Similarly, no significant differences were noted in the proportion of patients with SO at study entry (1.8% in LDG vs 1.6% HDG; p = 0.99) and at 12 months (3.7% in LDG vs. 0.9% HDG; p = 0.18) across arms. …"
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Assessment of four dose calculation algorithms using IAEA-TECDOC-1583 with medium dependency correction factor (K_med) application حسب Aram Rostami (22045274)

"…</p><h3>Conclusions</h3><p dir="ltr">This study highlights the significant impact of applying K_med on dose differences between measurement and calculation during the dose audit process.…"

Dosage, time, and polytherapy dependent effects of different levetiracetam regimens on cognitive function حسب Jon Davis Perkins (17885747)

"…</p><h3>Significance</h3><p dir="ltr">When taken in small doses, for brief periods as monotherapy, levetiracetam minimally influences cognition.…"

Pharmacokinetics of single‐dose rivaroxaban under fed state in obese vs. non‐obese subjects: An open‐label controlled clinical trial (RIVOBESE‐PK) حسب Majdoleen Alalawneh (13961580)

"…Rivaroxaban's exposure was similar between the obese and non‐obese subjects, and there were no significant differences in other pharmacokinetic parameters between the two groups. …"

Bioequivalence of losartan/amlodipine fixed dose combination tablets (losanet AM) compared with concomitant administration of Single components of losartan and amlodipine tablets i... حسب Bustami, Rana

"…The analysis of variance did not show any significant difference between the two formulations and 90% confidence intervals fell within the acceptable range for bioequivalence (80-125%). …"
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... حسب Masri, Oussama Samer

"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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Assessment of water quality variations on pretreatment and environmental impacts of SWRO desalination حسب Abdulrahman Al-Kaabi (17075194)

The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention حسب Almonzer Al-Qiami (22393303)

"…No statistically significant difference in mean arterial pressure was observed between the two groups (MD -5.15, 95% CI [-10.38 to 0.08 mmHg], <i>P</i> = 0.09). …"

Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults حسب Khaddaj, Rashel

"…Furthermore, the change between both groups was significantly different (-7.61 ±4.03 in the Vitamin D group, -3.50±1.54 in the control group; p=<0.001) Conclusion: The present study shows thata 50.000 IU/week dose of vitamin D supplementation for 3 months was enough to increase vitamin D levels beyond sufficient and decrease depression symptoms in Saudi Arabian Adults. …"
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Recent advances in the treatment and outcome of locally advanced rectal cancer حسب Abdalla, Eddie

"…Results There were 219 patients in the early era and 109 in the late era. No significant differences were seen in patients (age, gender, race) or tumor characteristics (mean distance from the anal verge, annularity, fixation). …"
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study حسب Husham Abdelrahman (768893)

"…Head injury and bleeding were the leading causes of mortality in the study cohort. There was a significant decrease in the trend of geriatric trauma over the years. …"