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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
منشور في 2021"…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …"
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Association of polycythemia vera with positive JAK2V617F mutation and myasthenia gravis: A report of two cases
منشور في 2023"…<p></p><div> <p>Screening for MG in patients with PV positive for JAK2V617F mutation can help in early diagnosis and treatment, resulting in a significant reduction in morbidity and mortality.…"
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Positive Epstein-Barr virus polymerase chain reaction in a case of acute retinal necrosis
منشور في 2012"…He had panuveitis with significant vitreous haze and retinal necrosis nasally (Fig. 1). …"
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The Impact of Adopting Positive Education and Wellbeing Culture on Learners with Special Educational Needs and Disabilities (SEND) in a Private and Mainstream School in Dubai: An E...
منشور في 2020"…While it has been demonstrated that the role of positive education and wellbeing culture is vital to the optimal development of students within school settings, scrutiny and reluctance to employ novel techniques present a significant challenge and a never-ending list of “to-dos” that hinder the opportunity to ensure an ideal school environment. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
منشور في 2023"…Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. …"
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Economic Development and COVID-19 Cases
منشور في 2020"…In terms of death cases, the number of infections, the share of geriatric population and the lack of systematic BCG vaccination all play a positive and significant role.…"
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Optimizing patellar positioning during total knee arthroplasty
منشور في 2017"…Results Our results demonstrated that, (a) a significant morphological difference of the patellar cut exists between men and women (P < 0.0001), and (b) with reference to centre of the patellar cut, the OCPP lies superiorly and medially in 89%, inferiorly and medially in 9.4%, laterally and superiorly in 1.6%, and in no case laterally and inferiorly. …"
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Efficacy and safety of the newer oral hypoglycemic agents in patients with T2DM during Ramadan: A systematic review and meta-analysis
منشور في 2020"…Dipeptidyl peptidase-4 inhibitors (DPP-4i) led to a significant reduction in Hb<sub>A1c</sub> (%) (SMD -0.25) and a non-significant decrease in weight (kg) (SMD -1.06) during Ramadan. …"
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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
منشور في 2024"…Single-cell analysis revealed high RFX6 expression levels in endocrine clusters across various hESC-derived pancreatic differentiation stages. Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …"
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Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
منشور في 2021"…HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. …"
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The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis
منشور في 2020"…</p><h3>Conclusions</h3><p dir="ltr">This systematic review and meta-analysis shows that Ramadan-focused diabetes education leads to a decrease in HbA1c and LDL, but an increase in TG and weight during Ramadan. …"