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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
منشور في 2017"…As perturbations in the aforementioned pathways are well documented in multiple diseases, Sestrin2 might serve as a potential therapeutic target for various diseases. …"
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Treating Cancers Using Nature’s Medicine: Significance and Challenges
منشور في 2021"…In recent decades, the emphasis on identifying therapeutic plant-based active principles led to significant advancements in the identification and use of natural compounds to treat various diseases (Figure 1) [2,3]. …"
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Extracellular vesicles as tools and targets in therapy for diseases
منشور في 2024"…Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. …"
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Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
منشور في 2025"…Deregulation of glutamine metabolism significantly influences various pathological conditions, including cancers and metabolic and neurological diseases. …"
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Inflammatory Markers and COVID-19 Disease Progression
منشور في 2023"…All markers, except procalcitonin, demonstrated a significant correlation with disease severity. These results could enhance our understanding of COVID-19 pathogenesis and help predict and manage severe cases.…"
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Olodaterol for the treatment of chronic obstructive pulmonary disease
منشور في 2016"…In 48- and 6-week Phase III clinical trials of olodaterol evaluating various lung function and symptomatic outcomes in patients with moderate to very severe COPD, olodaterol use was associated with significant improvements in spirometry outcomes, such as postbronchodilator forced expiratory volume in one second (FEV1), as well as dyspnea severity and quality-of-life measures. …"
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Cutting‐edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges
منشور في 2024"…However, the industry is facing several difficulties, including infectious diseases, the most significant limiting factor for aquaculture expansion. …"
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Machine Learning Based Palm Farming: Harvesting and Disease Identification
منشور في 2024"…The purpose of this work is two-fold: 1) date fruit bunch type and ripeness classification, 2) classification of healthy and three stages of white-scale disease (WSD) infested date palm leaflets. For this purpose, we utilize deep learning (DL) models by adding additional layers and optimizing various parameters to enhance their performance for these specific tasks. …"
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The Use of the Gene Expression Omnibus (GEO) Database to Study Gene Expression and Methylation Patterns in Cases of Preterm Birth and Associated Diseases
منشور في 2023"…</p> <h3>Conclusion</h3> <p>The utilization of GEO to analyse gene expression and methylation patterns in cases of PTB and associated diseases has linked various significant genes in potentially impacting such cases. …"
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A novel method for the detection and classification of multiple diseases using transfer learning-based deep learning techniques with improved performance
منشور في 2024"…<p dir="ltr">A disease is a distinct abnormal state that significantly affects the functioning of all or part of an individual and is not caused by external harm. …"
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Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review
منشور في 2024"…<h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. …"
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Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy
منشور في 2020"…Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer.…"
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Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity
منشور في 2022"…Similarly, reduced levels of various triacylglycerols were also observed in hypertensive patients corresponding with increased disease severity, including those containing palmitic, oleic (C18:1), and docosahexaenoic acids. …"
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Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort
منشور في 2021"…As expected, patients with severe disease showed significantly higher antibody titers and interestingly also had significantly broader epitope coverage. …"
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15
ALOX5AP gene variants show differential association with coronary artery disease in different populations
منشور في 2010"…Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. …"
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An examination of how climate change could affect the future spread of Fusarium spp. around the world, using correlative models to model the changes
منشور في 2023"…The plant pathogenic fungus Fusarium is known for causing crop diseases like blight, root and stem rots, and wilts, making it the most significant mycotoxigenic genus in weeds and food across various climatic zones worldwide. …"
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Isolated pulmonary cryptococcosis in a patient with Crohn's disease treated with infliximab: A case report and literature review
منشور في 2021"…<p dir="ltr">Tumor necrosis factor-alpha (TNF-α) inhibitors are widely used to treat various inflammatory conditions, where they have demonstrated excellent efficacy and tolerability. …"
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Genetic evaluation of cardiomyopathies in Qatar identifies enrichment of pathogenic sarcomere gene variants and possible founder disease mutations in the Arabs
منشور في 2021"…<h3>Background</h3><p dir="ltr">Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are serious inherited heart diseases with various causative mutations identified. …"
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Revisiting high-density lipoprotein cholesterol in cardiovascular disease: Is too much of a good thing always a good thing?
منشور في 2024"…<p dir="ltr">Cardiovascular disease (CVD) continues to be a leading cause of global mortality and morbidity. …"
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Restless legs syndrome in multiple sclerosis patients: Prevalence, impact, and association with disease-modifying therapies in a Saudi Arabian pilot study
منشور في 2023"…Furthermore, additional research endeavors are warranted to elucidate the diverse impact of various disease-modifying therapies on clinical outcomes.…"