-
1
-
2
-
3
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
-
5
-
6
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
7
Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
-
8
-
9
-
10
Implementing and leading technology-driven pedagogical change: A Study among Teachers from Selected Schools in Abu Dhabi
منشور في 2025"…Findings reveal that visionary leadership, strategic planning and collaborative professional development are critical for successful technology integration, while resistance to change and resource limitations pose significant challenges. The implications suggest that policymakers and school leaders should prioritise evidence-based strategies, targeted training and alignment with broader educational goals to sustain technology-driven reforms. …"
احصل على النص الكامل
-
11
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
-
12
Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
منشور في 2021"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
13
-
14
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
15
The Role of School Leaders In Supporting Inclusive Educational Practices through Continuous Professional Developments: A Study among Selected Primary Schools in Abu Dhabi
منشور في 2024"…Effective leadership practices, collaboration and cultural sensitivity emerged as critical factors. Policy implications underscore the need for refining inclusive education guidelines. …"
احصل على النص الكامل
-
16
Investigating the Effectiveness and Teachers’ Perceptions of Rigorous Curriculum Design for Project-Based Learning Implementation on Middle School Science Students’ Achievement and...
منشور في 2023"…Since countries’ educational systems accountability is currently evaluated based on student’s achievements in external benchmark assessments and while students are still underperforming in benchmark assessments particularly Measure of Academic Progress (MAP) in the United Arab Emirates (UAE) this study aimed to Investigate the Effectiveness and Teachers’ Perceptions of RCD for PBL Implementation on Middle School Science Students’ Achievement and MAP scores in a Private School in Abu Dhabi, UAE. Methods: Guided by the perspectives of Vygotsky’s social constructivist theory and Dewey’s experiential learning theory, an explanatory sequential mixed method design was used in this study. …"
احصل على النص الكامل
-
17
-
18
-
19
-
20