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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Development and Validation of the Motivation for Tutoring Questionnaire in Problem-Based Learning Programs
منشور في 2017"…PurposeThere are no published instruments, which measure tutor motivation for conducting small group tutorials in problem-based learning programs. Therefore, we aimed to develop a motivation for tutoring questionnaire in problem-based learning (MTQ-PBL) and evaluate its construct validity. …"
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احصل على النص الكامل
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A Literature Based Examination of Human Error in Military Aviation Maintenance Management Programs
منشور في 2018"…This study examines human error associated with the military aviation maintenance management programs. The rationale behind this study was based on the rising human error that comes along with military aviation maintenances. …"
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Adherence and retention to the self-managed community-based Step Into Health program in Qatar (2012–2019)
منشور في 2022"…<h3>Purpose</h3><p dir="ltr">Investigate adherence and retention to the “Step Into Health (SIH)” initiative (www.stepintohealth.qa [website access only available from within the State of Qatar]), a Qatari self-managed community-based health program, from 2012 to 2019. </p><h3>Methods</h3><p dir="ltr">Participants (16,711; 16–80 years; 37% females, 34% Qatari) used a pedometer or smartphone application (app) to measure step count. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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The impact of strategy diffusion on organisational performance of project-based organisations
منشور في 2021"…This study used a quantitative method to investigate the influence of strategy diffusion on organisational performance within project-based organisations, where significant positive influences on the relationships were found between the required research variables. …"
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Non-Linear Programming-Based Energy Management for a Wind Farm Coupled with Pumped Hydro Storage System
منشور في 2022"…A random forest (RF) method is used to perform the power forecasting after the extraction of the weather data features using a kernel principal component analysis (KPCA) technique. Then, a nonlinear programming (NLP)-based optimization technique is proposed to define the day-ahead optimal energy of the PHES. …"
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Degree-Based Network Anonymization
منشور في 2020"…A corresponding graph realization approach is introduced based on a reduction to the Weighted Edge Cover problem, which in turn is solved using Integer Linear Programming to obtain the best possible solution. …"
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احصل على النص الكامل
masterThesis -
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Hemodynamics of small aneurysm pairs at the internal carotid artery
منشور في 2012"…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…"
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احصل على النص الكامل
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
منشور في 2006احصل على النص الكامل
doctoralThesis -
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"