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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Oral contraceptive pills and possible adverse effects
منشور في 2014"…COCs are contraindicated for women with increased cardiovascular risk, increased thromboembolic risk, significant liver disease, systemic lupus erythematosus, or migraine with aura. …"
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
منشور في 2021"…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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Hedonic valuation of land protection methods: implications for cluster development.
منشور في 2014"…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …"
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Prevalence, Associated Risk Factors, and Adverse Cardiovascular Outcomes of Statins Discontinuation: A Systematic Review
منشور في 2024"…Five studies that reported the cardiovascular risk of statin discontinuation within the first year of initiation showed significantly increased risk of discontinuation, including all‐cause mortality (hazard ratio: 1.36–3.65).…"
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Pravastatin plus L-arginine prevents adverse pregnancy outcomes in women with uteroplacental vascular dysfunction
منشور في 2021"…</p><h3>Objective</h3><p dir="ltr">The aim of this pilot non randomized control study was to use pravastatin +L-arginine to improve uteroplacental haemodynamics and prevent adverse maternal and neonatal outcomes in women with abnormal Dopplers and high risk for developing adverse pregnancy outcomes.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Retrospective identification of medication related adverse events in the emergency medical services through the analysis of a patient safety register
منشور في 2022"…Prehospital medication related adverse events remain a significant threat to patient safety in this setting and warrant greater widespread attention and future identification of strategies aimed at their reduction.…"
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Factors that influence patient and public adverse drug reaction reporting: a systematic review using the theoretical domains framework
منشور في 2023"…<h3>Background</h3><p dir="ltr">Only 5–10% of all adverse drug reactions (ADRs) are reported. Mechanisms to support patient and public reporting offer numerous advantages to health care systems including increasing reporting rate. …"
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
منشور في 2006احصل على النص الكامل
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
منشور في 2025"…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"
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The effects of Ramadan fasting on clinical and biochemical markers among hemodialysis patients: A prospective cohort study
منشور في 2019"…Additionally, RFG and RPFG had significant increase in mean serum potassium as compared to RNFG. …"
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