Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems حسب Local Burden of Disease HIV Collaborators (13279180)

"…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …"

Re-examining post-acceptance model of information systems continuance: A revised theoretical model using MASEM approach حسب Anubhav, Mishra

"…The analysis included 1,056 observations on fifteen relationships from 214 independent studies with a combined sample of 84,343. The results confirm the significance of all the relationships proposed in the original model. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer حسب Markar, Sheraz R.

"…Propensity matched analysis confirmed that R1 resection margin was significantly associated with reduced overall survival and increased overall, locoregional, and mixed tumor recurrence. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Hedonic valuation of land protection methods: implications for cluster development. حسب Kling, Robert

"…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …"
احصل على النص الكامل

Hemodynamics of small aneurysm pairs at the internal carotid artery حسب Jou, Liang-Der

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Re-examining post-acceptance model of information systems continuance: A revised theoretical model using MASEM approach حسب Anubhav Mishra (17380600)

"…The analysis included 1,056 observations on fifteen relationships from 214 independent studies with a combined sample of 84,343. The results confirm the significance of all the relationships proposed in the original model. …"

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"

Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed حسب Bartholomew, Aaron

احصل على النص الكامل

Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma حسب Abou-Ghazal, Mohamed

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

"…Western blotting results revealed an upregulation in Bax:Bcl‑2 ratio, confirming the pro‑apoptotic effect of kefir, and an increase in p53 independent‑p21 expression upon kefir treatment. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis حسب Ahmad R. Al-Qudimat (17337808)

"…Meta-regression analysis results also showed a statistically significant association between hypertension and COVID-19 mortality.…"

Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser حسب Salem, Hayder

احصل على النص الكامل

Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines حسب Mansour, Najwa

"…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance حسب Zouhaier Farhani (22330693)

"…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"

Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Diseas... حسب Parkes J Kendrick (9714851)

Percutaneous coronary intervention can be safely performed with left ventricular thrombus without increasing stroke risk: A 5-year retrospective review using real-world data حسب Mohanad Shehadeh (17860691)

"…<h3>Introduction</h3><p dir="ltr">Left ventricular thrombus (LVT) increases the risk of ischemic stroke. However, it remains uncertain if the percutaneous coronary intervention (PCI) in the confirmed LVT setting further augments the stroke risk. …"

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... حسب Marissa B Reitsma (8674341)

The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …"

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... حسب Abdoulaye Diane (14152749)

"…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…"