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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Determinants of Off-Balance Sheet Business in the Case of GCC Banking Sectors during Covid-19
منشور في 2025احصل على النص الكامل
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Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla
منشور في 2022"…Significant differences were observed among the two major gut phyla, Firmicutes (F) and Bacteroidetes (B), where deficient subjects displayed a higher B/F ratio (p = 0.0097) compared to ND. …"
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Lymph Node Ratio Is an Independent Prognostic Factor After Resection of Periampullary Malignancies
منشور في 2014"…Objective: The prognostic impact of nodal involvement in resected pancreatic carcinoma and biliary malignancy has been relatively well established. …"
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Neutrophil‐to‐Lymphocyte Ratio Predicts Dialysis Timing & Prognosis in Critically Ill Patients
منشور في 2025"…<h3>Background and Aims</h3><p dir="ltr">The neutrophil‐to‐lymphocyte ratio (NLR) is a cost‐effective indicator of inflammation, which may impact decisions regarding therapy for patients undergoing continuous renal replacement therapy (CRRT), even with ongoing clinical arguments. …"
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Pyrolysis of biosolids with waste cardboard: effect of operating parameters, feedstock size and blending ratio
منشور في 2023"…A significant effect with change in blending ratio and a minimal effect by varying particle size was observed on the biochar yield. …"
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CFD modeling of particle settling in drilling fluids: Impact of fluid rheology and particle characteristics
منشور في 2021"…The current article provides a Computational Fluid Dynamics (CFD) modeling study of particle settling behavior during the drilling operations, with a special focus on the impact of fluid rheology, flow regime, particle size and shape on the settling rate. …"
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
منشور في 2019"…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …"
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Glass Selection for High-Rise Buildings in the United Arab Emirates Considering Orientation and Window-to-Wall Ratio
منشور في 2015"…Both papers are for a study that considers the relationship among the glass thermal characteristics, its cost, and the price of electricity. This paper significantly expands the study by adding commercial buildings typology, considering two major building orientations and taking into account five different window-to-wall ratios. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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article