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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
منشور في 2019"…</p><h3>Objective</h3><p dir="ltr">Identification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used anonymized internet search engine data to investigate which medical conditions and symptoms preceded searches for 12-step meeting locators and general 12-step information.…"
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
منشور في 2019"…Leaders’ capacity to think about abstract and complex ideas has long been acknowledged as essential to leadership tasks such as planning and analysis; however, because conceptualisation is often ambiguous and difficult to understand, many frameworks of leadership and change lack clarity on the actual significance of leaders’ conceptual skills when leading change. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Preparation of Mesoporous/Microporous MnCo<sub>2</sub>O<sub>4</sub> and Nanocubic MnCr<sub>2</sub>O<sub>4</sub> Using a Single Step Solution Combustion Synthesis for Bifunction Oxy...
منشور في 2020"…Chronoamperometric (CA) runs for 24 h shows excellent stability of MnCo<sub>2</sub>O<sub>4</sub> without any significant decrease in the current or potential value in ORR and OER. …"
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A novel hybrid methodology for fault diagnosis of wind energy conversion systems
منشور في 2023"…Feature selection pre-processing is an important step to increase the accuracy of the classification algorithm and decrease the dimensionality of a dataset. …"
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Supporting secure dynamic alert zones using searchable encryption and graph embedding
منشور في 2023"…Furthermore, we investigate the more challenging case of dynamic alert zones, where the area of interest changes over time. Our extensive experimental evaluation shows that our solutions can significantly improve computational overhead compared to existing baselines.…"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …"
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Effect of Strain Fields on Frequency Band Gaps of Periodic Lattice-Based Metamaterials
منشور في 2024"…Varying the topology of lattice metamaterials has been shown to affect their acoustic properties significantly. However, this work focuses on the effect of morphological changes, particularly stretching, on their acoustic properties. …"
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Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development
منشور في 2021"…This was followed by prioritization of candidate variants through several filtering steps. In the molecular part, we isolated two cellular populations from two patients: a control and a patient with a CL/P phenotype typical of van der Woude syndrome (VWS). …"
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masterThesis